细胞毒素相关蛋白A阳性幽门螺杆菌感染与胃癌的相关性及对生长抑素、核因子κB和环氧合酶2的影响

发布时间：2018-04-04 20:05

本文选题：细胞毒素相关蛋白A　切入点：幽门螺杆菌　出处：《中华医院感染学杂志》2017年03期

【摘要】：目的探讨细胞毒素相关蛋白A(CagA)阳性幽门螺杆菌(Hp)感染与胃癌的相关性及对生长抑素、核因子κB(NF-κB)和环氧合酶2(COX-2)的影响。方法随机选择2014年3月-2016年5月128例胃黏膜病变且Hp感染的患者为研究对象,其中慢性浅表性胃炎44例(浅表组),萎缩性胃炎38例(萎缩组),胃癌46例(胃癌组),采用酶联免疫吸附法测定血清CagA-IgG及生长抑素水平,采用链酶卵白素-过氧化酶法(SP)检测NF-κB和COX-2。结果胃癌组CagA阳性率(73.9%)明显高于浅表组、萎缩组50.0%,52.6%,差异有统计学意义(P0.05);胃癌组生长抑素水平低于浅表组、萎缩组,萎缩组低于浅表组,差异有统计学意义(P0.05);3组CagA阳性患者生长抑素水平均低于同组CagA阴性患者,差异有统计学意义(P0.05);胃癌组NF-κB阳性及COX-2阳性率均高于浅表组、萎缩组,萎缩组均高于浅表组,差异有统计学意义(P0.05);萎缩组与胃癌组CagA阳性患者NF-κB阳性率均高于同组CagA阴性患者,胃癌组CagA阳性患者COX-2阳性率均高于同组CagA阴性患者,差异有统计学意义(P0.05)。结论 CagA阳性Hp感染与胃黏膜癌变有密切相关性,其更容易导致生长抑素水平降低,且更能增加NF-κB及COX-2阳性表达。
[Abstract]:Objective to investigate the relationship between Helicobacter pylori (HP) infection and gastric cancer and the effects on somatostatin, nuclear factor 魏 B (NF- 魏 B) NF- 魏 B and cyclooxygenase 2 (COX-2).Methods A total of 128 patients with gastric mucosal lesions and HP infection were randomly selected from March 2014 to May 2016.Among them, 44 cases of chronic superficial gastritis (superficial group), 38 cases of atrophic gastritis (atrophy group) and 46 cases of gastric carcinoma (gastric cancer group) were examined for serum CagA-IgG and somatostatin levels by enzyme linked immunosorbent assay (Elisa).The levels of NF- 魏 B and COX-2 were detected by streptavidin-peroxidase method (SPSP).Results the positive rate of CagA in gastric cancer group (73.9%) was significantly higher than that in superficial group (52.6%) in atrophy group (P < 0.05), and somatostatin level in gastric cancer group was lower than that in superficial group, atrophy group and atrophy group were lower than superficial group.The levels of somatostatin in CagA positive group were lower than those in CagA negative group, and the positive rates of NF- 魏 B and COX-2 in gastric cancer group were higher than those in superficial group, atrophy group and atrophy group were higher than superficial group.The positive rate of NF- 魏 B in CagA positive patients in atrophy group and gastric cancer group was higher than that in CagA negative group, and COX-2 positive rate in CagA positive group in gastric cancer group was higher than that in CagA negative group (P 0.05).Conclusion there is a close correlation between CagA positive HP infection and gastric mucosa carcinogenesis. It is more likely to lead to the decrease of somatostatin level and to increase the positive expression of NF- 魏 B and COX-2.
【作者单位】：南阳医学高等专科学校第一附属医院普通外科;南阳医学高等专科学校第一附属医院肿瘤内科;南阳医学高等专科学校第一附属医院消化内科;南阳医学高等专科学校第一附属医院检验科;南阳医学高等专科学校第一附属医院病理科;
【基金】：河南省卫生厅科技创新人才资助项目(201500210)
【分类号】：R57;R735.2

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