唾液胃蛋白酶含量与老年胃食管反流病的关系

发布时间：2018-04-05 15:06

本文选题：唾液胃蛋白酶　切入点：胃食管反流病　出处：《中国老年学杂志》2017年12期

【摘要】：目的探讨唾液中胃蛋白酶与胃食管反流病(GERD)的关系。方法 60例GERD患者依照病情不同分为反流性食管炎(RE)组、非糜烂性食管反流病(NERD)组及Barrett食管(BE)组,采用中国消化内镜学会标准(1998烟台)分级内镜下表现积分对患者临床症状进行评价,应用乳胶增强免疫比浊法分析患者唾液中胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ及总胃蛋白酶原水平。结果 RE组胃蛋白酶原Ⅰ水平显著高于NERD组和BE组,总胃蛋白酶原水平显著高于BE组(均P0.05);3组症状评分差异无统计学意义(P0.05);3组均有较佳的阴性预测值和敏感性;RE、NERD、BE组临床症状评分与唾液内胃蛋白酶原Ⅰ浓度均呈正相关(r=0.573,0.463,0.452;P0.05)。结论老年GERD患者唾液中胃蛋白酶水平与症状评分呈正相关,临床中可考虑通过检测患者唾液中胃蛋白酶水平分析老年GERD患者病情。
[Abstract]:Objective to investigate the pepsin and gastroesophageal reflux disease in saliva (GERD) relationship. Methods 60 cases of GERD patients with disease were divided into reflux esophagitis (RE) group, non erosive reflux disease (NERD) group and Barrett (BE) group, the esophageal China society of digestive endoscopy (standard Yantai 1998) classification of endoscopic manifestation integral to evaluate the clinical symptoms of patients with immune turbidimetry of pepsin in the saliva of patients with primary application of latex enhanced, pepsinogen II and total pepsinogen levels. Results in group RE, pepsinogen I was significantly higher than that of NERD group and BE group, the total pepsinogen levels were significantly higher in group BE (all P0.05); the 3 groups had no statistically significant difference in symptom score (P0.05); the 3 groups had better negative predictive value and sensitivity; RE, NERD, clinical symptom score of BE group and in the saliva of pepsinogen I concentrations were positively correlated (r=0.573,0.463,0.452; P0.05 Conclusion the pepsin level in saliva of elderly GERD patients is positively correlated with symptom score. In clinical practice, we can consider the detection of the level of pepsin in the saliva of patients, and analyze the condition of elderly patients with GERD.

【作者单位】：福建医科大学附属南平第一医院消化内科;
【基金】：南平市科技计划项目(N2015D03)
【分类号】：R571

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