丙氨酰-谷氨酰胺强化肠外营养对结肠癌合并肠梗阻患者炎症反应及免疫功能的调节作用

发布时间：2018-04-05 19:21

本文选题：丙氨酰-谷氨酰胺　切入点：肠外营养　出处：《中国现代医学杂志》2016年09期

【摘要】：目的探讨丙氨酰-谷氨酰胺强化肠外营养对结肠癌合并肠梗阻患者炎症反应及免疫功能的影响。方法选取100例结肠癌合并肠梗阻患者,分为观察组和对照组,每组50例。对照组仅给予标准肠外营养,观察组加用丙氨酰-谷氨酰胺100ml/d。比较两组手术前后血清前白蛋白、白蛋白、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平。统计患者住院期间并发症发生率。结果术前及术后3 d,两组患者血清前白蛋白、白蛋白、IgA、IgG、IgM、TNF-α、IL-6水平比较,差异无统计学意义(P0.05);术后7 d,与对照组比较,观察组患者血清前白蛋白、白蛋白、IgA、IgG、IgM水平增高(P0.05),TNF-α、IL-6水平降低(P0.05)。观察组并发症发生率低于对照组(4.0%vs 16.0%)(P0.05)。结论结肠癌合并肠梗阻围手术期采用丙氨酰-谷氨酰胺强化肠外营养,可显著增强营养,提高机体免疫力,抑制炎症反应,降低感染率,其效果优于标准肠外营养。
[Abstract]:Objective to investigate the effect of alanyl-glutamine-enhanced parenteral nutrition on inflammatory response and immune function in patients with colon cancer complicated with intestinal obstruction.Methods 100 patients with colon cancer complicated with intestinal obstruction were divided into observation group and control group with 50 cases in each group.The control group was given standard parenteral nutrition, and the observation group was treated with alanyl-glutamine 100 ml / d.The levels of serum prealbumin, albumin, immunoglobulin A (IgA), immunoglobulin G (IGG), immunoglobulin (IgM), tumor necrosis factor- 伪 (TNF- 伪), interleukin-6 (IL-6) were compared between the two groups before and after operation.The incidence of complications during hospitalization was counted.The incidence of complications in the observation group was lower than that in the control group (4.0 vs 16.0).Conclusion during perioperative period of colon cancer complicated with intestinal obstruction, alanyl-glutamine was used to strengthen parenteral nutrition, enhance body immunity, suppress inflammatory reaction and reduce infection rate. The effect of alanyl-glutamine is better than that of standard parenteral nutrition.
【作者单位】：广西壮族自治区北海市人民医院普通外科;
【分类号】：R735.35;R574.2

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