天津地区8577例慢性乙型肝炎病毒感染者血清标志物模式分析

发布时间：2018-04-06 02:03

本文选题：慢性乙型肝炎病毒感染　切入点：血清标志物　出处：《山东医药》2017年12期

【摘要】：目的探讨天津地区慢性乙型肝炎病毒(HBV)感染者的血清标志物模式及其特征。方法采用电化学免疫发光分析法对天津地区8 577例慢性HBV感染者的血清标志物进行定量检测,分析其模式组合方式,并按照年龄、性别进行分层研究。结果血清标志物共有18种不同组合模式,其中模式1(HBsAg+、HBeAb+、HBcAb+)占比例最高,为40.00%;其次为模式2(HBsAg+、HBeAg+、HBcAb+),所占比例为27.14%;特殊血清学模式(HBsAg+、HBsAb+)所占比例为5.50%。男性HBV感染者血清标志物模式1、2所占比例均高于女性(P0.05或0.01)。20~40岁年龄组血清标志物模式1、2所占比例分别为49.58%和62.16%,均高于其他年龄组(P0.05或0.01)。结论天津地区慢性HBV感染者以HBsAg+、HBeAb+、HBcAb+和HBsAg+、HBeAg+、HBcAb+为主要血清标志物模式;上述两种血清标志物模式在20~40岁年龄组所占比例最高,在男性感染者中所占比例均高于女性。
[Abstract]:Objective to investigate the pattern and characteristics of serum markers in patients with chronic hepatitis B virus (HBV) infection in Tianjin.Methods the serum markers of 8 577 patients with chronic HBV infection in Tianjin were quantitatively detected by electrochemiluminescence (ECL), and the pattern combination was analyzed, and stratified study was carried out according to age and sex.Results there were 18 different combinations of serum markers, among which the proportion of HBcAb was the highest (40.005), the second was 2(HBsAg (27.14%) and the special serological model (5.50%).The proportion of serum marker model 1- 2 in male patients with HBV infection was 49.58% and 62.16% respectively, which was higher than that of female patients (P 0.05 or 0.01g 路20g), respectively, which was higher than that of other age groups (P0.05 or 0.01).Conclusion HBsAg HBeAb and HBsAg HBeAg + HBcAb are the main serological markers of chronic HBV infection in Tianjin area, and the proportion of these two serological markers is the highest in the age group of 20 to 40 years old, and the proportion in male infection is higher than that in female.
【作者单位】：天津市第二人民医院天津市肝病医学研究所;天津医科大学;天津市第一中心医院;
【基金】：国家自然科学基金资助项目(30800974/81271845) 天津市卫生局科技基金重点项目(2012KR02);天津市卫生局科技基金攻关项目(12KG118)
【分类号】：R512.62

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