HLA-DRB1基因多态性与幽门螺杆菌感染相关性的系统评价

发布时间：2018-04-08 18:10

本文选题：HLA-DRB　切入点：幽门螺杆菌　出处：《现代预防医学》2016年15期

【摘要】：目的应用Meta分析的方法分析HLA-DRB1基因多态性与幽门螺杆菌感染的相关性。方法检索中文数据库包括中国知网、万方、维普,英文数据库包括Pub Med、MEDLINE、OVID。含有HLA-DRB1、幽门螺杆菌等相关的文献。数据提取后,将H.pylori感染患者作为病例组,H.pylori未感染患者作为对照组,采用Rev Man5.0进行分析,效应指标采用OR值和95%CI,异质性大小以I2进行表示。进行亚组分析和敏感性检验,用Egger’s法通过Stata12.0定量评估发表偏倚。结果 HLA-DRB1*08二组比较,差异有统计学意义。HLA-DRB1*1502二组比较,差异有统计学意义。对HLA-DRB1*08按照地区(欧洲与中国)进行亚组分析,二组比较,欧洲地区差异无统计学意义,中国地区差异有统计学意义。而按照H.pylori检验方法进行亚组分析,HLA-DRB1*1501,二组比较,联合试验差异有统计学意义,单项试验差异无统计学意义。HLA-DRB1*11,二组比较,联合试验Z=1.97(P=0.05),单项试验差异无统计学意义。结论 HLA-DRB1*08和HLA-DRB1*1502是H.pylori感染的易感基因。其中HLA-DRB1*08是中国地区特有的H.pylori感染易感基因。H.pylori检验方法是否作为HLA-DRB1*1501、*11的影响因素值得进一步分析研究。
[Abstract]:Objective to analyze the association between HLA-DRB1 gene polymorphism and Helicobacter pylori infection by Meta analysis.Methods Chinese database was searched including Chinese Web, Wanfang, Weipu, and English database including Pub MedMed MEDLINE OVID.Contains HLA-DRB1, Helicobacter pylori and other related literature.After the data was extracted, the patients with H.pylori infection were used as the control group, the Rev Man5.0 was used to analyze the effect index, OR value and 95% CI were used, and the heterogeneity was expressed by I2.Subgroup analysis and sensitivity test were performed. Publication bias was quantitatively evaluated by Stata12.0 using Egger's method.Results the difference between HLA-DRB1*08 group and HLA-DRB1 + 1502 group was statistically significant.The subgroup analysis of HLA-DRB1*08 according to region (Europe and China) showed that there was no significant difference between the two groups, but there was significant difference in China.Conclusion HLA-DRB1*08 and HLA-DRB1*1502 are susceptible genes to H.pylori infection.Among them, HLA-DRB1*08 is a unique H.pylori infection susceptibility gene in China. Whether the method of H.pylori test is the influential factor of HLA-DRB1h1501M11 is worthy of further analysis and study.
【作者单位】：华北理工大学公共卫生学院流行病与卫生统计学学科;唐山钢铁集团责任有限公司医院;
【基金】：唐山市科技科学技术研究与发展指导项目(111302092a)
【分类号】：R573

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