中国西南地区汉族人群PRSS1基因多态性与慢性胰腺炎的关系

发布时间：2018-04-10 04:16

本文选题：慢性胰腺炎　切入点：阳离子胰蛋白酶原　出处：《山东医药》2017年10期

【摘要】：目的探讨中国西南地区汉族人群中阳离子胰蛋白酶原(PRSS1)基因单核苷酸多态性(SNP)与慢性胰腺炎(CP)的关系。方法收集西南地区汉族人群样本864例,其中确诊CP患者384例(CP组),体检健康者480例(对照组);选取PRSS1基因rs10273639、rs6667和rs2011216 3个位点,采用单碱基延伸法检测SNP位点,分析其与CP的相关性。结果 rs6667位点G等位基因频率在CP组和对照组中分别为37.8%、29.8%,GG基因型频率分别为14.1%、7.5%,两组比较P均0.05;rs2011216位点G等位基因频率在CP组和对照组中分别为33.2%、26.5%,GG基因型频率分别为10.4%、6.0%,两组比较P均0.05;rs10273639等位基因及基因型在CP组与对照组比较差异无统计学意义。二元Logistic回归分析,rs6667位点G等位基因携带者患CP的风险是A等位基因的1.18倍,在显性模式[(AG+GG)vs AA]和隐性模式[GG vs(AG+AA)]下CP组患病风险分别是对照组的1.18、1.76倍;rs2011216位点G等位基因携带者患CP的风险是A等位基因的1.16倍,在显性模式[(AG+GG)vs AA]和隐性模式[GG vs(AG+AA)]下CP组患病风险分别是对照组的1.17、1.34倍;rs10273639位点下显性模式[(TC+CC)vs TT]和隐性模式[CC vs(TC+TT)]在CP组与对照组比较差异均无统计学意义。结论 PRSS1基因rs6667和rs2011216的SNP位点可能是中国西南地区汉族人群CP的易感基因位点。
[Abstract]:Objective to investigate the relationship between single nucleotide polymorphism (SNPN) of the cationic trypsinogen PRSS1 gene and chronic pancreatitis (CP) in the Han population of Southwest China.Methods A total of 864 Han nationality samples from southwest China were collected, including 384 patients with CP and 480 healthy controls (control group), and three loci of PRSS1 gene rs10273639 rs6667 and rs2011216 were selected, and SNP loci were detected by single base extension method.The correlation between CP and CP was analyzed.Results the G allele frequencies of rs6667 locus in CP group and control group were 37.8 and 29.8, respectively. The frequency of GG genotype was 14.1and 7.5in CP group and control group, respectively. The G allele frequency of P 0.05 rs2011216 locus in CP group and control group was 33.226.5 GG genotype frequency in CP group and control group, respectively.There was no significant difference in alleles and genotypes between the two groups (P 0.05 rs10273639) between the CP group and the control group.In binary Logistic regression analysis, G allele carriers at rs6667 locus were 1.18 times more likely to have CP than those with A allele.In the dominant mode [AG GG)vs AA] and the recessive mode [GG vs(AG AA], the risk of CP in CP group was 1.18 ~ 1.76 times higher than that of A allele in G allele carriers at rs2011216, respectively.There was no significant difference between CP group and control group in the dominant mode (AG GG)vs AA) and recessive model (GG vs(AG AAA). The risk of CP group was 1.17rs10273639 (P < 0.05). There was no significant difference between the CP group and the control group in the dominant mode [TC CC)vs TT] and the recessive pattern (CC vs(TC TTT).Conclusion the SNP loci of rs6667 and rs2011216 in PRSS1 gene may be susceptible to CP in Han population of Southwest China.
【作者单位】：电子科技大学附属医院·四川省人民医院;电子科技大学医学院;
【基金】：四川省干部保健科研基金(川干研2016-203) 四川省科技厅基金资助项目(2011FZ0036) 四川省人民医院青年基金(2015QN19)
【分类号】：R576

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