非酒精性脂肪肝患者并发2型糖尿病的风险分析

发布时间：2018-04-10 07:44

本文选题：非酒精性脂肪性肝　切入点：型糖尿病　出处：《山东医药》2015年03期

【摘要】：目的分析非酒精性脂肪性肝(NAFLD)患者并发2型糖尿病的风险。方法通过计算机检索Pubmed、Embase和Web of Science数据库中NAFLD和2型糖尿病风险关联关系的队列研究相关的文献。采用Stata12.0软件进行Meta分析,计数资料采用RR及其95%CI表示,对NAFLD和2型糖尿病发生的风险采用随机效应模型分析。结果纳入11篇队列研究,其中前瞻性研究6篇(73 205例),回顾性研究5篇(39 975例)。11篇研究中共有113 322例参加者、5 776例2型糖尿病。在2型糖尿病的发生风险上,NAFLD患者比非NAFLD患者高2倍(RR=2.05,95%CI为1.63~2.57,P0.001)。轻度NAFLD和重度NAFLD患者的2型糖尿病风险分别为1.57(95%CI为1.08~2.30,P0.01)和2.92(95%CI为1.69~5.09,P0.001)。结论 NAFLD并发2型糖尿病的风险较大。
[Abstract]:Objective to analyze the risk of type 2 diabetes in patients with NAF LDD.Methods the cohort studies on the association between NAFLD and type 2 diabetes mellitus were searched by computer in Pubmedmedus Embase and Web of Science databases.The Meta analysis was carried out by Stata12.0 software, the counting data were expressed by RR and 95%CI, and the risk of NAFLD and type 2 diabetes was analyzed by random effect model.Results 11 cohort studies were conducted, including 6 prospective studies (73 205 cases) and 5 retrospective studies (39 975 cases). A total of 113 322 participants were involved in 5 776 cases of type 2 diabetes.The risk of type 2 diabetes mellitus was 2 times higher in NAF LD patients than in non NAFLD patients.The risk of type 2 diabetes in patients with mild NAFLD and severe NAFLD were 1.080.30g / P0.01 and 1.690.09 / P0.001, respectively.Conclusion the risk of NAFLD complicated with type 2 diabetes is higher.
【作者单位】：青岛大学附属医院;
【分类号】：R587.1;R575.5

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