ω-3鱼油脂肪乳静脉注射对重症急性胰腺炎患者炎症反应的影响

发布时间：2018-04-12 21:24

  本文选题：重症急性胰腺炎 + ω-鱼油脂肪乳　； 参考：《山东医药》2015年37期

【摘要】：目的观察静脉注射(静注)ω-3鱼油脂肪乳对重症急性胰腺炎患者全身炎症反应的影响。方法将40例重症急性胰腺炎患者随机分为研究组和对照组,各20例。两组在给予抗感染,抑制胰酶分泌、胰酶活性,营养支持等治疗的基础上分别静脉注射ω-3鱼油脂肪乳(研究组)和等渗盐水(对照组),治疗7 d后采用全自动生化分析仪和ELISA法检测两组CRP、降钙素原(PCT)、肿瘤坏死因子α(TNF-α)、IL-6水平,并对两组进行急性生理与慢性健康评分(APACHE-Ⅱ评分)。结果研究组、对照组治疗前CRP分别为(130.6±12.8)与(120.2±13.1)mg/L,PCT分别为(20.4±4.0)与(21.2±4.3)μg/L,TNF-α分别为(70.4±18.7)与(69.8±17.6)ng/L,IL-6分别为(295.6±67.7)与(302.4±65.6)μmol/L,APACHE-Ⅱ评分分别为(17.5±6.4)与(17.8±8.2)分。研究组、对照组治疗后CRP分别为(34.9±11.5)与(58.4±12.1)mg/L,PCT分别为(5.4±3.5)与(10.2±4.2)μg/L,TNF-α分别为(20.5±15.4)与(42.3±14.5)ng/L,IL-6分别为(201.4±64.5)与(254.5±66.3)μmol/L,APACHE-Ⅱ评分分别为(10.3±4.2)与(14.3±5.7)分,两组治疗前后及治疗后两组间各指标比较,P均0.05。结论静注ω-3鱼油脂肪乳可降低重症急性胰腺炎患者全身炎症反应程度。
[Abstract]:Objective to observe the effect of intravenously injected 蠅 -3 fish oil fat emulsion on systemic inflammation in patients with severe acute pancreatitis.Methods 40 patients with severe acute pancreatitis were randomly divided into study group and control group with 20 cases each.The two groups were given anti-infection, inhibition of pancreatic enzyme secretion, trypsin activity,On the basis of nutritional support and other treatments, 蠅 -3 fish oil fat emulsion (study group) and isosmotic saline (control group) were injected intravenously respectively. After 7 days of treatment, the levels of CRP, procalcitonin, TNF- 伪, TNF- 伪 and IL-6 were measured by automatic biochemical analyzer and ELISA.The acute physiological and chronic health scores (APACHE- 鈪，

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