肝脏疾病微RNA胞间传递研究的现状与思考

发布时间：2018-04-13 16:38

本文选题：微RNAs + 肝脏疾病　；参考：《中国生物化学与分子生物学报》2015年07期

【摘要】：微RNA(microRNAs)是一类通过调控基因表达参与机体生理、病理过程的非编码RNA.近来,研究证实其可在肝脏不同类型细胞间进行传递,以调控靶细胞的功能,从而参与肝脏疾病的发生发展.但其在不同类型肝脏细胞间传递的直接实验证据——细胞共培养实验仍需考虑:不同类型细胞在共培养时的数量比例及miRNAs在不同细胞间传递的方向.miRNAs的胞间传递作为肝脏疾病病理机制的重要理论创新,在研究过程中仍需要考虑临床实践.本文对近期关于微RNA胞间传递与肝脏疾病的研究进行综述,以期促进对相关研究的思考.
[Abstract]:MicroRNAs microRNAss are a class of non-coding RNAs that participate in physiological and pathological processes by regulating gene expression.Recently, it has been demonstrated that it can be transfered between different types of cells in the liver to regulate the function of target cells and thus participate in the occurrence and development of liver diseases.But the direct experimental evidence of its transmission between different types of liver cells-cell co-culture experiment still needs to consider: the number of different types of cells in co-culture and the direction of miRNAs transmission between different cells .miRNAs intercellular transmissionAs an important theoretical innovation in the pathological mechanism of liver diseases,Clinical practice still needs to be considered in the course of research.In this paper, the recent studies on intercellular transmission of micro and liver diseases were reviewed in order to promote the related research.
【作者单位】：哈尔滨医科大学基础医学院生物化学与分子生物学教研室;哈尔滨医科大学北方转化医学研究与合作中心;黑龙江省医学科学院基础医学研究所;
【基金】：哈尔滨医科大学于维汉院士杰出青年培养基金黑龙江博士后青年英才计划及博士后资助项目(No.LBH-Z12172/LBH-TZ0415) 高等学校博士学科点专项科研基金(No.20122307110002) 黑龙江省应用技术研究与开发计划项目(No.2013G1002)~~
【分类号】：R575

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