前列腺素E治疗老年失代偿期乙型肝炎肝硬化的临床疗效及安全性

发布时间：2018-04-14 06:05

本文选题：失代偿期乙型肝炎肝硬化 + 前列腺素E　；参考：《中国老年学杂志》2015年20期

【摘要】：目的探讨前列腺素E治疗老年失代偿期乙型肝炎肝硬化的临床疗效及其安全性。方法选取该院传染病科收治的老年失代偿期乙型肝炎肝硬化患者90例,随机分为两组,每组45例,对照组予阿昔洛韦80 mg+200 ml 5%葡萄糖,20滴/min,1次/d静脉滴注,拉米夫定100 mg1次/d口服,螺内酯片60 mg 3次/d口服,呋塞米30 mg 1次/d口服,根据患者尿量酌情调整剂量,2 w为1个疗程,治疗2个疗程;实验组在常规治疗的基础上加用前列腺素E 10μg+200 ml 5%葡萄糖,20滴/min,1次/d静脉滴注,2 w为1个疗程,治疗2个疗程。治疗结束后,对比治疗前后患者谷丙转氨酶(ALT)、谷草转氨酶(AST)、血清白蛋白、血清球蛋白、血清白蛋白与血清球蛋白比值及随诊结果。结果 1治疗前两组患者ALT、AST比较无显著差异;治疗后,观察组的ALT、AST水平明显低于对照组(P0.05);2治疗后两组患者指标均有改善,且实验组血清白蛋白、血清球蛋白、血清白蛋白与血清球蛋白比值较对照组明显好转(P0.05);3随诊实验组患者无不良反应及并发症,明显优于对照组(P0.05);结论前列腺素E能够明显提高老年失代偿期乙型肝炎肝硬化的临床疗效,安全性高,对临床具有指导意义,值得临床推广。
[Abstract]:Objective to investigate the clinical efficacy and safety of prostaglandin E (PGE) in the treatment of elderly patients with decompensated hepatitis B cirrhosis.Methods 90 elderly patients with decompensated hepatitis B cirrhosis were randomly divided into two groups, 45 patients in each group. The control group was given acyclovir 80 mg 200ml 5% glucose 20% / min once a day intravenously.Lamivudine 100 mg1 / d, spironolactone 60 mg / d, furosemide 30 mg / d, respectively.The experimental group was treated with prostaglandin E (10 渭 g, 200 渭 g, 200 渭 g, 5% glucose, 20 drops / d, intravenously for 2 weeks) as a course of treatment.After the treatment, the ratio of alanine aminotransferase (alt), alanine aminotransferase (alt), aspartate, serum albumin, serum globulin, the ratio of serum albumin to serum globulin and follow-up results were compared before and after treatment.Results 1 there was no significant difference between the two groups before and after treatment, after treatment, the levels of alt AST in the observation group were significantly lower than those in the control group (P 0.05) and the indexes of the two groups were improved, and the serum albumin and globulin were improved in the experimental group.The ratio of serum albumin to globulin was better than that of control group.Conclusion prostaglandin E can significantly improve the clinical efficacy and safety of aged patients with decompensated hepatitis B cirrhosis.
【作者单位】：无锡市第五人民医院肝科;
【基金】：无锡市科技局社会发展项目(No.CSE01009)
【分类号】：R512.62;R575.2

【参考文献】