苦参素治疗老年乙肝肝硬化的效果及对门脉血流动力学的影响

发布时间：2018-04-14 08:09

  本文选题：苦参素 + 乙肝　； 参考：《中国老年学杂志》2017年13期

【摘要】：目的探讨苦参素治疗老年乙肝肝硬化的疗效及对门脉血流动力学的影响。方法 96例老年乙型肝硬化患者随机分为对照组和观察组各48例,对照组予常规治疗,观察组加用苦参素胶囊,24 w为1个疗程。比较病毒活性、肝纤维化指标和门脉血流动力学,记录不良反应。结果治疗后观察组乙型肝炎病毒(HBV)-DNA转阴率高于对照组(P0.05)。观察组肝纤维化指标透明质酸(HA)、Ⅳ型胶原(ⅣC)和层黏连蛋白(LN),门脉血流动力学指标门静脉及脾静脉的平均流速及脾静脉血流量改善均较对照组明显(P0.05)。其余指标相近。两组均未观察到明显不良反应。结论苦参素治疗老年慢性乙肝肝硬化安全且有效。
[Abstract]:Objective to investigate the effect of matrine on liver cirrhosis and portal hemodynamics in elderly patients.Methods 96 elderly patients with cirrhosis B were randomly divided into control group (n = 48) and observation group (n = 48). The control group was treated with routine therapy and the observation group was treated with matrine capsule for 24 weeks as a course of treatment.Virus activity, hepatic fibrosis index and portal hemodynamics were compared, and adverse reactions were recorded.Results the negative rate of HBV-DNA in the observation group was higher than that in the control group (P 0.05).Compared with the control group, the indexes of hepatic fibrosis, such as hyaluronate, collagen type 鈪，

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