RAS对各肝病影响的研究进展

发布时间：2018-04-14 22:23

  本文选题：肾素-血管紧张素系统 + 肝炎　； 参考：《基因组学与应用生物学》2017年01期

【摘要】：肾素-血管紧张素系统(rennin angiotensin system,RAS)是机体内重要的具有调节血压、水钠平衡等功能的内分泌调节系统。近年在各肝病的研究中发现,RAS失衡与各种肝病的发生与发展均有密切关系。肝组织内存在局部的完整RAS系统,当肝细胞或肝组织受到某种致病因素的刺激时,局部RAS被激活,各成分活性增强并重新分布,继而影响肝病的发展。早期研究已证实ACE-AngⅡ-AT1R轴表达上调可加重肝脏损伤,促进各肝病的进展。新近研究发现的ACE2-Ang(1-7)-Mas轴被不断证明是ACE-AngⅡ-AT1R轴的反向调节轴,被称为"替代RAS经典轴",发挥拮抗ACE-AngⅡ-AT1R轴的作用,对肝病的进展起一定的缓解或逆转作用。本研究就近年来关于RAS对各肝病的影响的相关研究做一综述,为找到更有效的缓解和治愈肝病的新方法提供新思路。
[Abstract]:Renin-angiotensin system (Ras) is an important endocrine regulatory system with the functions of regulating blood pressure, water and sodium balance.In recent years, it has been found that the imbalance of Ras is closely related to the occurrence and development of various liver diseases.There is a complete local RAS system in the liver tissue. When the liver cells or liver tissues are stimulated by some pathogenic factors, the local RAS is activated, and the activity of each component is increased and redistributed, which affects the development of liver disease.Early studies have confirmed that the up-regulation of ACE-Ang 鈪，

本文编号：1751252