不同胆结石患者血浆和肠黏膜组织中D-乳酸及DAO活性观察

发布时间：2018-04-14 23:17

本文选题：胆石症 + 肠黏膜通透性　；参考：《山东医药》2015年18期

【摘要】：目的探讨胆石症患者血浆和肠黏膜组织的D-乳酸及二胺氧化酶(DAO)活性变化的临床意义。方法选择105例胆石症患者作为观察组,分析结石性质,对比患者血浆和肠黏膜组织的D-乳酸及二胺氧化酶(DAO)活性,并与健康对照组比较。结果根据结石化学性质,胆色素结石患者所占比例最高,为44.76%,其次为胆固醇结石,混合性结石最低;胆色素结石患者血浆与肠黏膜的D-乳酸活性显著低于对照组、胆固醇结石者及混合性结石者,DAO活性显著高于对照组、胆固醇结石者及混合性结石者(P均0.05)。除胆色素结石外,不同性质和部位的结石患者血浆与肠黏膜的D-乳酸活性及DAO活性比较差异均无统计学意义,与对照组相比差异亦无统计学意义。结论胆色素结石患者血浆与肠黏膜的D-乳酸活性较低、DAO活性较高,肠黏膜受损更严重。
[Abstract]:Objective to investigate the clinical significance of the changes of D-lactic acid and diamine oxidase (diamine oxidase) activity in plasma and intestinal mucosa in patients with cholelithiasis.Methods 105 patients with cholelithiasis were selected as the observation group, the stone properties were analyzed, and the activities of D-lactic acid and diamine oxidase oxidase (DAO) in plasma and intestinal mucosa of the patients were compared with those in the healthy control group.Results according to the chemical properties of the stones, the proportion of patients with pigment gallstone was the highest (44.76), the second was cholesterol stone, the lowest was mixed stone, the activity of D-lactic acid in plasma and intestinal mucosa of patients with gallstone was significantly lower than that of the control group.The activity of Dao in cholesterol calculi and mixed calculi was significantly higher than that in the control group (P < 0.05).There was no significant difference in D- lactic acid activity and DAO activity between plasma and intestinal mucosa in patients with gallstone with different properties and locations except for pigment gallstone, and there was no significant difference compared with the control group.Conclusion the activity of D-lactic acid in plasma and intestinal mucosa in patients with gallstone is higher than that in patients with choledocholithiasis, and the damage of intestinal mucosa is more serious.
【作者单位】：莒县人民医院;滨州医学院;
【基金】：滨州市科技发展计划资助项目(2010ZC0768)
【分类号】：R575.62

【共引文献】