乙肝肝硬化患者HBVDNA水平与细胞毒性T淋巴细胞表面程序性死亡受体-1表达及肝功能的关系

发布时间：2018-04-15 21:30

本文选题：肝硬化 + 乙型肝炎肝硬化　；参考：《实用医学杂志》2015年07期

【摘要】：目的:探讨乙型肝炎肝硬化患者血清HBV DNA水平与外周血HBV特异性细胞毒性T淋巴细胞(CTL)表面程序性死亡受体-1(PD-1)表达及肝功能的关系。方法:将109例HBV DNA阳性、HBe Ag阳性和人白细胞抗原(HLA)-A2阳性的乙型肝炎肝硬化患者根据HBV DNA水平分为2组,甲组52例,HBV DNA 2~4 log10拷贝/m L,乙组57例,HBV DNA 5~7 log10拷贝/m L,比较2组患者的HBV特异性CTL表面PD-1表达、HBV特异性CTL水平和肝功能的差异。结果:甲组HBV特异性CTL表面PD-1表达低于乙组(t=11.101,P0.01),HBV特异性CTL水平高于乙组(t=24.424,P0.01),丙氨酸氨基转移酶低于乙组(t=2.652,P0.01),血清白蛋白高于乙组(t=2.347,P0.05)。Child-pugh分级,甲组C级低于乙组(χ2=4.262,P0.05)。结论 :乙型肝炎肝硬化患者血清HBV DNA水平高者,HBV特异性CTL表面PD-1表达水平高,因此,HBV特异性CTL水平低,进一步导致HBV DNA水平升高,导致肝功能损害较重,HBV DNA水平低者,HBV特异性CTL表面PD-1表达水平低,HBV特异性CTL水平高,预示抗病毒疗效相对较好。
[Abstract]:Objective: to investigate the relationship between serum HBV DNA level and the expression of programmed death receptor (PD-1) on the surface of peripheral blood HBV specific cytotoxic T lymphocytes (HBV) and liver function in patients with hepatitis B cirrhosis.Methods: 109 patients with hepatitis B cirrhosis with HBV DNA positive and human leukocyte antigen HLA-A2 positive were divided into two groups according to the HBV DNA level.The expression of HBV-specific CTL on the surface of HBV specific CTL on the surface of HBV specific CTL was compared in 52 patients of group A and 57 patients of group B and 57 patients of group B, respectively. The expression of HBV-specific CTL on the surface of HBV specific CTL and liver function were compared between the two groups.Results: the expression of PD-1 on the surface of HBV specific CTL in group A was lower than that in group B (11.101), and the level of specific CTL in group A was higher than that in group B (24.424), the level of alanine aminotransferase was lower than that in group B (2.652), and the level of serum albumin in group A was higher than that in group B (T2.347P0.05N. Child-pugh grade), and the level of C in group A was lower than that in group B (蠂 2 4.262P 0.05).Conclusion: the higher serum HBV DNA level in patients with hepatitis B cirrhosis is, the higher the PD-1 expression level on HBV-specific CTL surface is, therefore, the lower HBV-specific CTL level leads to the further increase of HBV DNA level.The lower level of PD-1 expression on the surface of HBV-specific CTL and the higher the level of HBV-specific CTL in patients with severe liver function damage, the lower the level of HBV-specific CTL, which indicates that the antiviral effect is relatively good.
【作者单位】：江苏省无锡市第五人民医院(无锡市传染病医院)肝病科;
【分类号】：R512.62;R575.2

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