幽门螺杆菌感染与炎症性肠病关系的临床研究

发布时间：2018-04-22 06:36

本文选题：幽门螺杆菌 + 溃疡性结肠炎　；参考：《新乡医学院》2017年硕士论文

【摘要】：背景幽门螺杆菌(Helicobacter pylori,HP)是慢性胃炎、消化性溃疡、胃癌及胃粘膜相关性淋巴组织淋巴瘤的主要病因。近年来,有证据表明HP感染可通过免疫调节作用对某些免疫相关的疾病如过敏性哮喘、变应性皮炎等发挥保护作用;IBD的病因和发病机制尚未完全明确,异常活跃的免疫反应被认为是IBD发病的主要因素,有研究表明HP感染对IBD的发生具有保护作用,目前二者之间的关系仍有争议。本文通过研究初次诊断的IBD患者中HP感染情况,以期明确HP感染与IBD的关系。目的明确HP感染与IBD的关系。方法采用1:2配比病例对照研究,严格按照病例组和对照组的纳入和排除标准,选取100例初次诊断的IBD患者为病例组,选择同时期就诊的经肠镜检查结果无器质性病变或正常的200例健康体检者为对照组,年龄、性别与病例组相匹配。采用酶联免疫吸附法(ELISA)检测血清Hp-IgG水平,Hp-IgG阳性者诊断为HP感染,比较病例组和对照组的HP感染情况,运用Logistic回归分析HP感染与IBD的相关性,并根据表型特征、病变程度的不同对IBD患者进行分组,分别比较各亚组间的HP感染率有无差异。结果IBD组HP感染率为39.00%,低于对照组(59.00%),差异有统计学意义(P0.05),经Logistic回归分析,HP感染与IBD呈负相关(OR=0.450 95%CI=0.274-0.737P=0.002)。不同表型特征的IBD患者中的HP感染率差异无统计学意义(P0.05)。不同病变严重程度的IBD患者中的HP感染率差异无统计学意义(P0.05)。结论1.HP感染可能是IBD发病的保护性因素;2.HP感染与IBD的表型特征无相关性;3.HP感染与IBD的病变严重程度无明显相关性。
[Abstract]:Background Helicobacter pylori (Helicobacter pylori) is the main cause of chronic gastritis, peptic ulcer, gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma. In recent years, there has been evidence that HP infection can protect some immune-related diseases such as allergic asthma and allergic dermatitis through immunomodulation. The etiology and pathogenesis of IBD have not been completely clarified. Hyperactive immune response is considered to be the main factor in the pathogenesis of IBD. Some studies have shown that HP infection has protective effect on the occurrence of IBD, and the relationship between the two is still controversial. HP infection in patients with IBD was studied in order to determine the relationship between HP infection and IBD. Objective to investigate the relationship between HP infection and IBD. Methods A 1:2 matched case-control study was carried out. According to the inclusion and exclusion criteria of the case group and the control group, 100 patients with IBD were selected as the case group. In the same period, 200 patients who had no organic lesion or normal physical examination were selected as control group, age, sex and case group were matched. HP infection was detected by Elisa in patients with positive serum Hp-IgG level and Hp-IgG. HP infection was compared between case group and control group. Logistic regression analysis was used to analyze the correlation between HP infection and IBD, and according to phenotypic characteristics. Patients with IBD were divided into groups with different degree of lesion to compare the HP infection rate among subgroups. Results the HP infection rate in IBD group was 39.00, which was lower than that in control group (P 0.05). There was a negative correlation between HP infection and IBD by Logistic regression analysis. There was no significant difference in HP infection rate among IBD patients with different phenotypic characteristics (P 0.05). There was no significant difference in HP infection rate among IBD patients with different severity of disease (P 0.05). Conclusion 1.HP infection may be a protective factor in the pathogenesis of IBD. 2. There is no correlation between HP infection and phenotypic characteristics of IBD. 3. There is no significant correlation between HP infection and severity of IBD.
【学位授予单位】：新乡医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R574

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