隐匿性乙肝与肝细胞肝癌关系的研究进展

发布时间：2018-04-24 01:15

本文选题：肝细胞肝癌 + 隐匿性乙肝　；参考：《重庆医科大学学报》2015年03期

【摘要】：慢性乙肝是肝细胞肝癌(hepatocellular carcinoma,HCC)发生的主要危险因素已是公认的定论,那么隐匿性乙肝(occult hepatitis B virus infection,OBI)与HCC的相关性如何,却尚有争议。此文综合国内外临床和动物研究结果,总结出:OBI是HCC发生的重要危险因素。OBI保留有显性乙型肝炎病毒(hepatitis B virus,HBV)感染相同的致癌机制,如整合进宿主基因组,顺式激活相关基因或合成蛋白后反式作用于基因组或相关蛋白质,如合成乙肝病毒X蛋白(hepatitis B virus X antigen,HBX)、前S蛋白和乙肝表面抗原(hepatitis B surface antigen,HBs Ag),这些蛋白可使肝细胞发生转化,影响信号通路,使细胞增殖、凋亡失衡。其次,持续存在的低载量病毒可导致轻微但持续的炎症坏死,肝细胞循环坏死、再生,加速肝硬化进程,最终导致HCC。最后,病毒突变及甲基化修饰在HCC发生中也有重要作用。
[Abstract]:Chronic hepatitis B is the main risk factor for the development of hepatocellular carcinoma (HCC), but the relationship between occult hepatitis B virus infection OBI and HCC is still controversial. Based on the clinical and animal studies at home and abroad, it is concluded that: OBI is an important risk factor for HCC. Obi retains the same carcinogenic mechanism of dominant hepatitis B virus infection, such as integration into host genome. Cis activates genes or synthetic proteins and transacts on genomes or proteins, such as hepatitis B virus X antigenin HBX, pre-S protein and hepatitis B surface antigen-HBs Agna, which can transform hepatocytes. Affect signal pathway, make cell proliferation, apoptosis imbalance. Secondly, the persistent low load virus can cause mild but persistent inflammatory necrosis, hepatocyte circulatory necrosis, regeneration, accelerate the progression of liver cirrhosis, and ultimately lead to HCC. Finally, viral mutation and methylation also play an important role in the pathogenesis of HCC.
【作者单位】：重庆医科大学附属第一医院感染科、重庆市传染病寄生虫病学重点实验室;
【基金】：国家自然科学基金资助项目(编号:30972587)
【分类号】：R512.62;R735.7

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