黄芩汤辅助柳氮磺吡啶对溃疡性结肠炎患者血清TNF-α及白介素族水平影响研究

发布时间：2018-04-25 06:34

本文选题：溃疡性结肠炎 + 柳氮磺吡啶　；参考：《中华中医药学刊》2017年02期

【摘要】：目的:探讨黄芩汤辅助柳氮磺吡啶对溃疡性结肠炎患者血清TNF-α及白介素族水平的影响。方法:选取研究对象为74例溃疡性结肠炎患者,随机分成对照组和治疗组,每组37例。对照组给予柳氮磺吡啶治疗,治疗组在上述基础上再予黄芩汤治疗,两组均治疗1个月,测定治疗前后血清白介素族及TNF-α,免疫球蛋白水平和结肠黏膜菌群,观察疗效及安全性。结果:与治疗前比较,两组血清IL~(-1)β、IL-6及TNF-α水平明显降低(P0.05),IL~(-1)0水平明显升高(P0.05),血清Ig A及Ig G水平明显降低(P0.05),结肠黏膜双歧杆菌及乳酸菌数量明显升高(P0.05),大肠杆菌数量明显降低(P0.05);与对照组比较,治疗组血清IL~(-1)β、IL-6及TNF-α水平较低(P0.05),IL~(-1)0水平较高(P0.05),血清Ig A及Ig G水平较低(P0.05),结肠黏膜双歧杆菌及乳酸菌数量较高(P0.05),大肠杆菌数量较低(P0.05),治疗有效率较高(P0.01),不良反应发生率较低(P0.05)。结论:黄芩汤辅助柳氮磺吡啶能提高对溃疡性结肠炎的疗效,其可能机制为调整肠道菌群,调节免疫以及不同血清白介素的水平。
[Abstract]:Objective: to investigate the effect of Huangqin decoction on serum TNF- 伪 and interleukin-伪 levels in patients with ulcerative colitis. Methods: 74 patients with ulcerative colitis were randomly divided into control group (n = 37) and treatment group (n = 37). The control group was treated with sulfasalopyridine, the treatment group was treated with Huangqin decoction on the above basis, and the two groups were treated for one month. Serum interleukin group and TNF- 伪, immunoglobulin level and colonic mucosal flora were measured before and after treatment, and the efficacy and safety were observed. Results: compared with before treatment, The levels of IL 6 and TNF- 伪 in serum of the two groups were significantly lower than those in the control group, and the levels of IL 6 and TNF- 伪 were significantly increased, the levels of Ig A and IgG were significantly decreased, the number of bifidobacterium and lactic acid bacteria in colonic mucosa were significantly increased, the number of Escherichia coli was significantly decreased, compared with the control group, the levels of Ig A and IgG were significantly decreased, and the number of Escherichia coli was significantly decreased compared with the control group. The serum levels of IL-6 and TNF- 伪 in the treatment group were lower than that in the control group. The levels of IL-6 and TNF- 伪 in the treatment group were higher than that in the control group. The levels of serum IgA and IgG were higher than those in the control group. The levels of serum IgA and IgG were lower (P0.05), the number of bifidobacterium and lactic acid bacteria in colon mucosa was higher (P0.05), the amount of Escherichia coli was lower (P0.05A), the effective rate of treatment was higher than that of P0.01, and the incidence of adverse reactions was lower (P 0.05). Conclusion: Huangqin decoction can improve the efficacy of salicylazosulfopyridine in the treatment of ulcerative colitis by adjusting intestinal flora, regulating immunity and the level of interleukin in different serum.
【作者单位】：宁波市第七医院消化内科;
【分类号】：R574.62

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