幽门螺杆菌感染对胃黏膜核因子NF-кB表达的影响研究

发布时间：2018-04-25 08:03

本文选题：幽门螺杆菌 + 感染　；参考：《中华医院感染学杂志》2016年17期

【摘要】：目的研究幽门螺杆菌(Hp)感染对胃黏膜中核因子NF-кB表达的影响,为慢性活动性胃炎的相关研究提供参考依据。方法选取2013年12月-2014年12月医院收治的慢性活动性胃炎患者104例为研究对象,根据患者Hp感染情况,分为Hp阳性组和Hp阴性组,各52例,对两组患者的NF-кB p65表达水平进行观察和比较,采用SPSS19.0软件进行统计分析。结果 Hp阳性组患者的NF-кB p65阳性细胞百分率为(48.98±18.34)%,显著高于Hp阴性组,差异有统计学意义(P0.05);胃黏膜炎症等级为1、2、3级的Hp阳性患者的NF-кB p65表达水平分别为(28.34±8.34)%、(41.38±9.44)%和(64.34±12.03)%,显著高于Hp阴性组,差异有统计学意义(P0.05);胃黏膜活动性等级为0、1、2级的Hp阳性患者的NF-кB p65表达水平分别为(32.91±11.45)%、(46.08±9.34)%和(64.32±12.30)%,显著高于Hp阴性组,差异有统计学意义(P0.05);胃黏膜萎缩等级为0、1、2级的Hp阳性患者的NF-кB p65表达水平分别为(40.56±19.34)%、(44.34±15.93)%和(54.32±15.03)%,显著高于Hp阴性组,差异有统计学意义(P0.05)。结论幽门螺杆菌感染可导致胃炎患者胃黏膜中核因子NF-кB表达水平升高,随着患者病情的不断进展NF-кB表达水平也呈现出升高趋势,NF-кB参与疾病的致病过程。
[Abstract]:Objective to study the effect of Helicobacter pylori (HP) infection on the expression of nuclear factor NF- B in gastric mucosa, and to provide reference for the study of chronic active gastritis. Methods 104 patients with chronic active gastritis from December 2013 to December 2014 were divided into HP positive group and HP negative group. The expression level of NF- FB p65 was observed and compared between the two groups. SPSS19.0 software was used for statistical analysis. Results the percentage of NF-p65 positive cells in HP positive group was 48.98 卤18.34, which was significantly higher than that in HP negative group, the difference was statistically significant (P 0.05), and the expression level of NF-T B p65 was 28.34 卤8.34 卤9.44% and 64.34 卤12.03m in HP positive patients with gastric mucosal inflammation grade (P < 0.05), respectively, which was significantly higher than that in HP negative group. The expression levels of NF-mb p65 in HP positive patients with gastric mucosal activity grade 0 ~ 1and grade 2 were 32.91 卤11.45% and 64.32 卤12.30%, respectively, which were significantly higher than those in HP negative group. The expression levels of NF-mb p65 in HP positive patients with gastric mucosal atrophy grade 0 ~ 1and grade 2 were 40.56 卤19.34% and 54.32 卤15.03%, respectively, which were significantly higher than those in HP negative group (P 0.05). Conclusion Helicobacter pylori infection can lead to an increase in the expression of nuclear factor NF- B in gastric mucosa of patients with gastritis.
【作者单位】：攀枝花市中心医院消化科;
【基金】：四川省科技厅科技攻关基金资助项目(20131387903K)
【分类号】：R573.3

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