胃食管反流病患者食管胃连接处形态及力学研究进展

发布时间：2018-04-27 14:15

本文选题：胃食管反流病 + 食管胃连接处　；参考：《山东医药》2017年34期

【摘要】：胃食管反流病(GERD)是一种临床常见的胃肠道动力障碍疾病之一,食管胃连接处(ECJ)抗反流机制减弱是其发生的主要的机制。近年来一直采用多种形态和力学参数来描述EGJ的抗反流屏障功能,其中食管下括约肌(LES)长度变短、LES静息压力降低是GERD发生的主要机制,并且可能是导致难治性GERD的重要因素之一;EGJ形态是抗反流功能的决定因素之一,LES和膈肌分离距离加大可能进一步促进GERD的发展,同样EGJ吸气压力降低是GERD发病的独立危险因素之一。食管胃交界处收缩指数(EGJ-CI)可综合评价EGJ的屏障功能,可以预测远端食管异常酸暴露以及酸反流,并且可以从烧心患者中辨别出GERD患者,可以补充或替代现有的基础LES以及EGJ参数,但未能实现自动算出EGJ-CI,未来对其也需要统一的计算方法。
[Abstract]:Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal motility disorders. In recent years, a variety of morphological and mechanical parameters have been used to describe the anti-reflux barrier function of EGJ. The decrease of resting pressure of les in lower esophageal sphincter is the main mechanism of GERD. And it may be one of the important factors leading to refractory GERD. The morphology of EGJ is one of the determinants of anti-reflux function. The increase of les and diaphragm separation distance may further promote the development of GERD. Similarly, reduced inspiratory pressure in EGJ is one of the independent risk factors for the onset of GERD. EGJ-CII can comprehensively evaluate the barrier function of EGJ, predict abnormal acid exposure and acid reflux in distal esophagus, and identify GERD patients from patients with heartburn. The existing basic LES and EGJ parameters can be supplemented or replaced, but the automatic calculation of EGJ-CI can not be realized, and a unified calculation method is needed in the future.
【作者单位】：遵义医学院附属医院;
【基金】：贵州省遵义市红花岗区科技项目(遵红科合社字2016-11号)
【分类号】：R571

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