非甾体类消炎药物与幽门螺杆菌感染对上消化道溃疡协同致病作用研究

发布时间：2018-04-27 15:57

本文选题：幽门螺杆菌 + 非甾体类消炎药　；参考：《中华医院感染学杂志》2015年23期

【摘要】：目的探讨幽门螺杆菌(Hp)感染和非甾体类消炎药(NSAIDs)对上消化道溃疡的协同致病作用,为临床治疗消化道溃疡提供理论指导。方法选取消化科于2014年3月-2015年3月收治的200例消化道溃疡患者作为观察组,将同期就诊的200例非消化道溃疡患者作为对照组,对两组患者Hp感染和服用NSAIDs进行调查,并分析其对上消化道溃疡的协同致病作用。结果 Hp感染服用NSAIDs的患者患胃溃疡的OR值明显比仅感染Hp者和仅服用NSAIDs者患胃溃疡之和高,差异有统计学意义(P0.05);Hp感染服用NSAIDs对十二指肠溃疡和胃溃疡患者,引发上消化道出血的OR值均明显比仅感染Hp者和仅服用NSAIDs者,引发上消化道出血的OR值之和低,差异有统计学意义(P0.05)。结论 Hp感染和NSAIDs对胃溃疡具有协同致病作用;而在溃疡合并上消化道出血中无协同致病作用;溃疡合并上消化道出血和服用NSAIDs的时长无关。
[Abstract]:Objective to investigate the synergistic effect of Helicobacter pylori (HP) infection and nonsteroidal anti-inflammatory drug (NSAIDs) on upper gastrointestinal ulcer and to provide theoretical guidance for clinical treatment of digestive tract ulcer. Methods 200 patients with digestive ulcer treated in Digestive Department from March 2014 to March 2015 were selected as observation group and 200 non-digestive ulcer patients as control group. HP infection and NSAIDs were investigated in both groups. The synergistic effect on upper gastrointestinal ulcer was analyzed. Results the OR value of gastric ulcer in patients with HP infection taking NSAIDs was significantly higher than that in patients only infected with HP and only taking NSAIDs. The difference was statistically significant in the patients with duodenal ulcer and gastric ulcer treated with NSAIDs. The OR values of upper gastrointestinal bleeding patients were significantly lower than those of patients only infected with HP and only taking NSAIDs. The difference was statistically significant (P 0.05). Conclusion HP infection and NSAIDs have synergistic pathogenicity on gastric ulcer, but there is no synergistic pathogenicity in ulcer complicated with upper gastrointestinal hemorrhage, and there is no correlation between NSAIDs duration and ulcer complicated with upper gastrointestinal bleeding.
【作者单位】：温州医科大学;温州市中西医结合医院消化内科;
【基金】：浙江省卫生厅基金资助项目(2013KYB252)
【分类号】：R573.1

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