18例何首乌相关性药物性肝细胞损害

发布时间：2018-04-29 02:09

本文选题：何首乌 + 肝毒性　；参考：《浙江大学》2014年硕士论文

【摘要】：研究目的何首乌是比较流行的中草药之一,在此系列病例回报中,我们报告了18例原本健康的非病毒性肝炎患者在服用何首乌(非复合制剂)后导致的肝功能损害。研究方法本研究同时采用了回顾性分析以及同时性观察研究,何首乌与肝损害的相关性分析严格遵守国际医学科学组织理事会标准(Council for International Organizations of Medical Sciences, CIOM)。研究结果从2005年至2012年,有18例何首乌相关性肝炎病人就诊于浙江大学附属第一医院,其中位年龄为42岁(年龄分布为18岁到63岁),潜伏期平均为27天(从1到120天),首先表现得临床症状主要为发力、食欲不振以及皮肤巩膜黄染。在18例患者中所有患者均有转氨酶的升高(AL140U/L, AST40U/L, GGT50U/L)同时有16位患者伴有总胆红素的升高(21mol/1),基于实验室检验指标以及CIOMS标准,所有患者的肝损类型均为肝细胞性肝损害,其相关性分析表明：18例患者中有14例表现为高度相关性。所有患者在入院后停用何首乌,并给予保肝护肝治疗后均得到好的转归。研究结论无论是生首乌还是制首乌,均可对非病毒性肝炎的健康人群造成肝功能损害。
[Abstract]:Research purpose Polygonum multiflorum is one of the most popular Chinese herbal medicines. In this series of cases we reported the liver function damage caused by 18 healthy patients with non-viral hepatitis after taking Polygonum multiflorum (non-composite). Research method Both retrospective analysis and simultaneous observation were used in this study. The correlation analysis between Radix Polygoni multiflorum and liver injury was strictly in accordance with the Council for International Organizations of Medical Sciences, CIOM. Research results From 2005 to 2012, 18 patients with polygonum multiflorum related hepatitis were admitted to the first affiliated Hospital of Zhejiang University. The age of the patients was 42 years (ranging from 18 to 63 years old) and the incubation period was 27 days (from 1 to 120 days). The clinical symptoms were mainly dysphoria, anorexia and yellowish skin sclera. In all of the 18 patients, all had elevated levels of alt 140 U / L, AST 40 U / L, GGT 50 / L) and 16 patients had elevated total bilirubin. Based on laboratory tests and CIOMS criteria, all patients had liver damage with hepatocytes. The correlation analysis showed that 14 out of 18 patients showed high correlation. All patients stopped using Polygonum multiflorum after admission and were treated with liver protection and liver protection. Research conclusion It can damage the liver function of healthy people with non-viral hepatitis.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R285.1

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