质子泵抑制剂联合康复新液对比质子泵抑制剂单药治疗反流性食管炎的Meta分析

发布时间：2018-04-30 03:37

本文选题：反流性食管炎 + 质子泵抑制剂　；参考：《中成药》2016年02期

【摘要】：目的评价质子泵抑制剂(PPI)联合康复新液(美洲大蠊干提取液)对比PPI单药治疗反流性食管炎的有效性和安全性。方法计算机检索The Cochrane Library、Pub Med、Embase、中国生物医学文献数据库(CBM)、相关期刊论文(CNKI)、维普中文科技期全文数据库(VIP)和万方数据库,对符合纳入标准的随机对照试验进行方法学质量评价,采用Rev Man 5.3进行Meta分析。结果共纳入5个研究402名患者,结果显示,PPI联合康复新液在临床症状疗效评价的显效率[OR=2.67,95%CI(1.69,4.21),P0.000 1]、总有效率[OR=4.90,95%CI(2.27,10.61),P0.000 1]优于PPI单药,胃镜疗效评价的治愈率[OR=1.87,95%CI(1.05,3.04),P=0.01]、总有效率[OR=5.55,95%CI(2.15,14.31),P=0.000 4]也优于PPI单药,而副反应,两组无显著差别(P=0.75)。结论现有证据表明,对于反流性食管炎的治疗,PPI联合康复新液优于PPI单药,但受纳入研究的数量及质量的影响,上述结论尚需更多高质量的临床试验来进一步证实。
[Abstract]:Objective to evaluate the efficacy and safety of proton pump inhibitor (PPI) combined with rehabilitation new solution (dry extract of Blattella Americana) in the treatment of reflux esophagitis with PPI. Methods The Cochrane Library Pub MedEmbase, China Biomedical Literature Database, China Journal Full-text Database, Weipu Chinese Science and Technology full text Database and Wanfang database were searched, and the methodological quality of randomized controlled trials that met the inclusion criteria were evaluated. Rev Man 5.3 was used for Meta analysis. Results A total of 402 patients were enrolled in 5 studies. The results showed that the effective rate of clinical symptom evaluation with PPI combined with new rehabilitation fluid [OR2.6795CI1.69 / 4.21 P0.0001], the total effective rate [OR4.9095CII 2.270.61P0.0001] was better than that of PPI alone, the cure rate of gastroscopy evaluation [OR1.87C95CI1.053.04P0.01], the total effective rate [OR5.5595CI2.151C2.31P0.0004] was also better than that of PPI alone. There was no significant difference in side effects between the two groups. Conclusion the available evidence shows that the treatment of reflux esophagitis combined with rehabilitation is superior to that of PPI alone, but it is affected by the quantity and quality of the included study, and more high quality clinical trials are needed to further confirm this conclusion.
【作者单位】：四川医科大学;南充市中心医院;四川省南充卫生学校;
【分类号】：R571

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