前列地尔对重症急性胰腺炎患者早期促炎因子的影响及疗效观察

发布时间：2018-05-07 22:19

本文选题：胰腺炎 + 急性坏死性　；参考：《解放军医学杂志》2017年02期

【摘要】：目的探讨前列地尔对重症急性胰腺炎(SAP)患者促炎因子表达变化的影响并进行临床疗效评估。方法收集2014年1月-2016年5月收治的SAP患者73例,随机分为对照组(37例)和试验组(36例)。在常规治疗(对照组)基础上,试验组给予前列地尔15μg/d。分别检测患者入院后1、3、7d血常规、C反应蛋白(CRP)、白细胞计数(WBC)、淀粉酶(AMY)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、肌酐(Cr)水平,同时检测血清促炎因子肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、白介素-6(IL-6)的表达变化。结果入院后1d,两组血常规、生化和各炎症指标均明显增高;随着治疗时间延长,各指标均逐渐降低,组内各时间点比较差异均有统计学意义(P0.05);两组各指标间比较差异均无统计学意义(P0.05)。随着治疗时间延长,各指标下降明显,至入院第3天和第7天,两组间各指标差异有统计学意义(P0.05)。结论静脉应用前列地尔可有效降低SAP患者早期炎症反应程度,减轻炎症损伤,对改善预后有重要意义。
[Abstract]:Objective to investigate the effect of alprostadil on the expression of proinflammatory factor in patients with severe acute pancreatitis (SAP). Methods from January 2014 to May 2016, 73 patients with SAP were randomly divided into control group (n = 37) and trial group (n = 36). On the basis of routine therapy (control group), the trial group was given prostadil 15 渭 g / d. The levels of CRP, WBC, amylase, alanine aminotransferase (alt), aspartate aminotransferase (aspartate transaminase) and creatinine (Cr) were measured at 1 ~ 3 ~ 7 days after admission in patients with CRP, WBC, amylase, alanine aminotransferase (alt), aspartate aminotransferase (AST) and creatinine (Cr). At the same time, the expression of TNF- 伪, IL-1 尾, IL-6 and TNF- 伪 in serum were detected. Results on the 1st day after admission, the blood routine, biochemical and inflammatory indexes in both groups were significantly increased, and with the prolongation of treatment time, the blood routine, biochemical and inflammatory indexes were decreased gradually. There were significant differences in each time point between the two groups (P 0.05), but there was no significant difference between the two groups (P 0.05). With the prolongation of treatment time, the indexes decreased obviously, and on the 3rd and 7th day of admission, the differences between the two groups were statistically significant (P 0.05). Conclusion intravenous administration of alprostadil can effectively reduce the degree of early inflammatory response and alleviate inflammatory injury in patients with SAP, and it is of great significance to improve the prognosis.
【作者单位】：南京医科大学金陵学院、南京军区总医院消化内科;
【基金】：南京军区保健专项科研课题(14BJZ28)~~
【分类号】：R576

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