奥曲肽联合大黄治疗急性胰腺炎的Meta分析

发布时间：2018-05-11 02:04

本文选题：奥曲肽 + 大黄属　；参考：《重庆医学》2015年24期

【摘要】：目的系统评价大黄与奥曲肽联用治疗急性胰腺炎的有效性和安全性。方法计算机检索中国生物医学文献数据库(CBM)、维普(VIP)、中国知网(CNKI)、PubMed和万方数据库,查找有关应用奥曲肽与大黄联用治疗急性胰腺炎的随机对照试验(RCT),并追索纳入文献的参考文献,检索时限:2008年1月至2014年12月。英文检索词为"Octreotide","rhubarb","ASP",中文检索词为"大黄"、"奥曲肽"、"急性胰腺炎"。2位评价员按照Corchrane系统评价方法,预先制定纳入标准和排除标准,对检索的文献进行独立筛选、数据提取和文献评估,交叉核对相关数据,使用RevMan 5.2软件分析。结果纳入10篇RCT,共655例受试者(试验组336例,对照组319例)。Meta分析结果显示:与单用奥曲肽相比,大黄联合奥曲肽可以提高显效率[RR=1.47,95%CI(1.21,1.78),P0.01]和总有效率[RR=1.19,95%CI(1.09,1.29),P0.01];试验组与对照组在缩短腹痛时间、血淀粉酶恢复时间、排便恢复时间、患者住院时间、腹胀消失时间、呕吐消失时间、尿淀粉酶恢复时间、腹压痛消失时间方面,均差异有统计学意义(P0.01);可降低转手术率,但差异无统计学意义(P0.05);两组安全性方面未见严重不良反应报道。结论与单用奥曲肽相比,奥曲肽联合大黄治疗急性重症胰腺炎能提高奥曲肽的临床疗效,安全性较好。
[Abstract]:Objective to evaluate the efficacy and safety of combined use of rhubarb and octreotide in the treatment of acute pancreatitis. Methods computer retrieval of Chinese biomedical literature database (CBM), VIP, CNKI, PubMed and Wanfang database were used to find a randomized controlled trial (RCT) for the treatment of acute pancreatitis with octreotide and rhubarb (RCT). Recourse to the reference literature, retrieval time limit: January 2008 to December 2014. English retrieval words "Octreotide", "rhubarb", "ASP", Chinese retrieval words "rhubarb", "octreotide", "acute pancreatitis".2 evaluators in accordance with the Corchrane system evaluation method, pre formulation of the inclusion criteria and exclusion criteria, independent screening of the literature for screening. Selection, data extraction and literature evaluation, cross checking related data, using RevMan 5.2 software analysis. The results were included in 10 RCT. A total of 655 subjects (336 cases in test group and 319 control group) showed.Meta analysis. Compared with octreotide, rhubarb combined octreotide could improve the efficiency of [RR=1.47,95%CI (1.21,1.78), P0.01] and total effective [RR =1.19,95%CI (1.09,1.29), P0.01], the test group and the control group had a significant difference in shortening the time of abdominal pain, the time of blood amylase recovery, the recovery time of defecation, the time of hospitalization, the time of disappearance of abdominal distention, the time of disappearance of vomit, the time of the recovery of urine amylase, and the disappearance time of abdominal pressure pain (P0.01), which could reduce the rate of operation, but the difference was no unification. No serious adverse reactions were reported in the two groups. Conclusion compared with octreotide alone, octreotide combined with rhubarb can improve the clinical efficacy of octreotide in the treatment of acute severe pancreatitis, and the safety is better.

【作者单位】：泸州医学院附属医院人力资源部;泸州医学院附属医院药学部;
【基金】：四川省卫生厅资助(130369)
【分类号】：R576

【参考文献】