输血感染未接受抗病毒治疗的HCVRNA阳性丙肝患者的疾病进展回顾性研究

发布时间：2018-05-11 02:37

本文选题：输血 + 丙型肝炎　；参考：《郑州大学》2014年硕士论文

【摘要】：目前在中国地区输血感染的丙型肝炎患者的疾病进展尚未得到系统的研究。根据我们的调查结果，在中国大部分因输血感染丙型肝炎病毒的患者感染史已经有20年，20年是慢性丙型肝炎很重要的评价时间点，可以用来评估输血感染未接受病毒治疗的HCVRNA阳性丙肝患者的疾病进展速度。我们对804例输血感染的丙肝患者进行了系统的回顾性队列研究。我们调查了代偿性肝硬化，失代偿性肝硬化和肝癌的发生并且分析了与疾病进展有关的危险因素。将肝硬化患者或肝癌患者归为严重进展组（serious development group，，SD group），剩下的患者归为肝炎组(hepatitis group，H group)。这两组患者在感染时的年龄，感染的时间段，观察时的年龄和观察时的丙型肝炎病毒RNA载量（P0.05）表现出了显著的差异。严重进展组的患者相对于肝炎组的患者明显感染时的年龄更大，有较长的感染丙型肝炎病毒的时间和较低的丙型肝炎病毒RNA载量。感染时的年龄在这些患者中是显著的肝癌的危险因素。我们的研究将对于预测输血感染未接受抗病毒治疗的HCVRNA阳性丙肝患者的疾病进展非常有帮助，目前年龄大于50岁的丙型肝炎患者已经表现出了显著的疾病进展并且我们相信越来越多的丙型肝炎患者将会在未来的十或二十年进展为肝硬化或者肝癌的。
[Abstract]:The progress of transfusion-infected hepatitis C patients in China has not been systematically studied. According to our findings, it has been 20 years since the majority of patients infected with hepatitis C virus infected with blood transfusion in China, and 20 years is a very important time point for the evaluation of chronic hepatitis C. It can be used to assess the rate of progression of HCVRNA-positive hepatitis C patients with transfusion infection without viral therapy. We conducted a systematic retrospective cohort study of 804 patients with hepatitis C infected by blood transfusion. We investigated the occurrence of compensatory cirrhosis, decompensated cirrhosis, and liver cancer and analysed the risk factors associated with the progression of the disease. The patients with liver cirrhosis or liver cancer were classified as serous development group SD group, and the rest patients were classified as hepatitis group. There were significant differences between the two groups in the age of infection, the time period of infection, the age of observation and the RNA load of hepatitis C virus (P0.05). Patients with severe progression had a longer duration of infection and lower RNA load of hepatitis C than those with hepatitis. Age at the time of infection is a significant risk factor for liver cancer in these patients. Our study will be very helpful in predicting the progression of HCVRNA positive hepatitis C patients with blood transfusion infection who are not receiving antiviral therapy. Hepatitis C patients over 50 years of age have shown significant progress and we believe that more and more patients with hepatitis C will develop cirrhosis or liver cancer in the next 10 or 20 years.
【学位授予单位】：郑州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R512.63;R457.1

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