盐酸小檗碱片治疗非酒精性脂肪性肝病疗效的Meta分析

发布时间：2018-05-13 02:12

本文选题：盐酸小檗碱片 + 非酒精性脂肪性肝病　；参考：《中国药房》2015年30期

【摘要】：目的:系统评价盐酸小檗碱片治疗非酒精性脂肪性肝病的疗效,以为临床治疗提供循证参考。方法:计算机检索相关期刊论文、万方数据库、中文科技期刊数据库、中国生物医学文献数据库及Pub Med,收集盐酸小檗碱片治疗非酒精性脂肪性肝病的观察性研究,提取资料并进行质量评价后采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入6项研究,合计294例患者。Meta分析结果显示,盐酸小檗碱片可显著降低非酒精性脂肪性肝病患者血清中天冬氨酸氨基转移酶[WMD=18.97,95%CI(2.25,35.70),P=0.03]、丙氨酸氨基转移酶[WMD=31.04,95%CI(7.17,54.91),P=0.01]、甘油三酯[WMD=1.07,95%CI(0.39,1.74),P=0.002]、总胆固醇[WMD=1.31,95%CI(0.79,1.84),P0.001]水平,治疗前后比较差异均有统计学意义。结论:盐酸小檗碱片可显著改善非酒精性脂肪性肝病患者的肝功能及血脂水平,临床疗效较为确切。受纳入研究方法学质量的限制,该结论有待大样本、高质量的随机对照试验进一步验证。
[Abstract]:Objective: to evaluate the efficacy of berberine hydrochloride tablets in the treatment of non-alcoholic fatty liver disease. Methods: the full text database of Chinese periodicals, Wanfang database, Chinese sci-tech journal database, Chinese biomedical literature database and Pub Medwere searched on the computer to collect the observation of berberine hydrochloride tablets in the treatment of non-alcoholic fatty liver disease. After extracting the data and evaluating the quality, Meta analysis was carried out with Rev Man 5.3 statistical software. Results: a total of 294 patients were included in 6 studies. Meta-analysis showed that, Berberine hydrochloride tablets could significantly reduce the levels of aspartate aminotransferase (WMD-18.9795 CIQ 2.2535.70), alanine aminotransferase (WMD-31.04N95CII 7.1754.91P0.01), triglyceride (WMD-1.0795% CI 0.391.74C), total [WMD1.31195 CI 0.790.84 P0.001], and the difference was statistically significant before and after treatment. Conclusion: berberine hydrochloride tablets can significantly improve liver function and blood lipid level in patients with non-alcoholic fatty liver disease. Limited by the quality of methodology included in the study, this conclusion needs to be further verified by a large sample of high quality randomized controlled trials.
【作者单位】：首都医科大学附属北京友谊医院;
【分类号】：R575.5

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