胃蛋白酶原与幽门螺杆菌抗体对十二指肠溃疡的筛查价值

发布时间：2018-05-14 18:34

  本文选题：胃蛋白酶原 + 抗幽门螺杆菌Ig　； 参考：《中国现代医学杂志》2015年05期

【摘要】：目的研究血清胃蛋白酶原(PG)与幽门螺杆菌(HP)抗体对十二指肠溃疡的筛查价值。方法选取2007年11月~2012年9月,在该院体检时发现的十二指肠溃疡50例,健康对照组为同期体检者,共50例,其中男女比例及年龄均与溃疡组相同。采用胶乳增强免疫透射比浊法检测血清胃蛋白酶原(PGⅠ、PGⅡ),并计算两者比值PGⅠ/PGⅡ(PGR);利用酶联免疫吸附试验法(ELISA)对受检者血清进行抗Hp-Ig G抗体检测。结果溃疡组中,PGⅠ与PGⅡ的浓度分别为(171.24±21.45)和(26.11±11.04)ng/ml,PGR为(8.18±1.09),PGⅠ、PGⅡ及PGR值明显高于对照组(P0.05)。溃疡组与对照组抗Hp-Ig G抗体阳性率分别为73.5%和20.6%,差异具有统计学意义(P0.05)。抗Hp-Ig G阳性组的PGⅠ与PGⅡ值分别为(159.05±21.24)和(22.74±11.16)ng/ml,PGR为(6.97±2.14),明显高于阴性组(P0.05)。结论异常血清胃蛋白酶原与抗Hp-Ig G抗体与十二指肠溃疡密切相关,并且可以作为溃疡早期的筛查指标。
[Abstract]:Objective to study the value of serum pepsinogen (PG) and Helicobacter pylori (HP) antibodies in the screening of duodenal ulcer. Methods from November 2007 to September 2012, 50 cases of duodenal ulcer were found in our hospital, and 50 cases of healthy control group were examined at the same time. The ratio of male and female and age were the same as those of ulcer group. Latex enhanced immunoturbidimetric assay was used to detect serum pepsinogen PG 鈪，

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