幽门螺杆菌感染与冠心病患者上消化道出血的相关性研究

发布时间：2018-05-14 20:25

本文选题：幽门螺杆菌 + 冠心病　；参考：《中华医院感染学杂志》2015年10期

【摘要】：目的探讨并分析幽门螺杆菌(Hp)感染与冠心病(CHD)患者上消化道出血的相关性,以降低CHD患者上消化道出血的发生率。方法随机选择医院2013年1月-2014年12月诊治的CHD上消化道出血患者58例,设为观察组,选择同时期诊治的CHD未发生上消化道出血患者79例作为对照组,采用回顾调查法观察两组患者基本情况,采用14 C尿素呼气试验检测患者Hp阳性率;测定血液总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)及C-反应蛋白(CRP)浓度。结果两组患者家族史、吸烟史、吸烟量、饮酒史、合并慢性病及体质量指数(BMI)等相关因素比较,差异无统计学意义,两组患者TG、TC、HDL和LDL结果比较,差异无统计学意义;观察组患者CRP为(57.13±2.27)mg/L,高于对照组的(31.45±2.41)mg/L,差异有统计学意义(P0.05);观察组14 C尿素呼气试验阳性率为67.24%,对照组为6.33%,观察组明显高于对照组,两组比较差异有统计学意义(P0.05)。结论 CHD上消化道出血是由多因素综合所致,Hp感染是一个独立危险因素,存在一定的相关性,临床上治疗CHD应减少患者Hp感染,以改善患者预后。
[Abstract]:Objective to investigate and analyze the relationship between HP infection and upper gastrointestinal hemorrhage in patients with coronary heart disease (CAD) in order to reduce the incidence of upper gastrointestinal hemorrhage in patients with CHD. Methods from January 2013 to December 2014, 58 CHD patients with upper gastrointestinal bleeding were randomly selected as observation group, and 79 patients with CHD without upper gastrointestinal bleeding were selected as control group. The basic conditions of the two groups were observed retrospectively. The positive rate of HP was detected by 14C urea breath test, and the concentrations of TCX, TGN, HDL-Cn, LDL-C and CRP were measured. Results there was no significant difference in family history, smoking, alcohol consumption, chronic disease and body mass index (BMI) between the two groups, but there was no significant difference between the two groups. The CRP of the observation group was 57.13 卤2.27 mg / L, which was higher than that of the control group (31.45 卤2.41 mg / L), and the positive rate of 14 C urea breath test was 67.24% in the observation group and 6.33 mg / L in the control group, and the difference between the two groups was statistically significant (P 0.05). Conclusion CHD upper gastrointestinal hemorrhage is an independent risk factor of HP infection caused by multiple factors. Clinical treatment of CHD should reduce HP infection in order to improve the prognosis of the patients.
【作者单位】：宁波市鄞州区第二医院急诊内科;
【基金】：浙江省中医药科技基金资助项目(2013ZB072)
【分类号】：R541.4;R573.2

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