模拟人类非酒精性肝病的小鼠模型

发布时间：2018-05-16 02:42

本文选题：非酒精性肝病 + 脂肪性肝炎　；参考：《生理科学进展》2017年05期

【摘要】：正非酒精性脂肪肝病(nonalcoholic fatty liver disease,NAFLD)为当前全球最常见慢性肝病,且呈低龄化趋势,其俗称为"脂肪肝";其病理特征,为肝细胞脂肪变性;其病因,可排除酗酒史及其他肝病因素;其发病率高,西方国家达15%~30%,我国达15%;该病初期,为单纯性脂肪肝(nonalcoholic simple fatty liver,NAFL)病情较稳定;然而,如发展到脂肪性肝炎(nonalcoholic steatohepatitis,NASH),则可进一步恶变为肝硬化、肝癌;脂肪性肝炎患病10~15年肝硬化率达15%~25%,其中约30%~
[Abstract]:Nonalcoholic fatty liver disease (NAF LDD) is the most common chronic liver disease in the world, and has a trend of low age, which is commonly called "fatty liver", its pathological features are hepatocyte steatosis, its etiology can exclude the history of alcoholism and other factors of liver disease. Its incidence is high, up to 1530 in western countries and 15 in our country; at the beginning of the disease, the disease is stable for nonalcoholic simple fatty liverNAFLL; however, if it develops into nonalcoholic steatohepatitis, it can be further transformed into cirrhosis and liver cancer. The rate of liver cirrhosis in 10 ~ 15 years of fatty hepatitis is 15%, about 30% of which is about 30%.
【分类号】：R-332;R575

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