布拉氏酵母菌治疗念珠菌食管炎临床疗效初探

发布时间：2018-05-16 14:04

本文选题：念珠菌食管炎 + 布拉氏酵母菌　；参考：《山西医科大学》2017年硕士论文

【摘要】：目的:通过药物临床试验对比布拉氏酵母菌与制霉菌素治疗念珠菌食管炎的临床疗效,探讨布拉氏酵母菌治疗念珠菌食管炎的临床疗效及安全性。方法:采用单中心、前瞻性、开放标签、随机对照的非劣性试验设计。将符合纳入标准和剔除标准念珠菌食管炎患者根据随机数字表法分为布拉氏酵母菌组(45例)和制霉菌素组(44例)。两组患者分别给予口服布拉氏酵母菌散和制霉菌素片治疗。疗程结束后复查胃镜以评价其疗效。采用非劣性检验比较两组治愈率差异。结果:布拉氏酵母菌组和制霉菌素组治愈率分别为68.9%和63.6%。采用非劣性检验计算得出统计量u=3.027,P=0.0013,拒绝无效假设,可认为布拉氏酵母菌治愈率非劣于制霉菌素。卡方检验比较两组有效率(分别为91.1%和93.2%)差异无统计学意义(P=1.000),而不良反应发生率分别为2.2%和22.7%,显示布拉氏酵母菌组明显低于制霉菌素组,差异有统计学意义(P=0.003)。结论:布拉氏酵母菌治疗念珠菌食管炎治愈率非劣于制霉菌素,且不良反应发生率低,可作为治疗念珠菌食管炎的治疗方案之一。
[Abstract]:Objective: To compare the clinical efficacy of yeast and nystatin in the treatment of Candida esophagitis, and to explore the clinical efficacy and safety of Candida esophagitis by Saccharomyces cerevisiae. Methods: a single center, prospective, open label, and randomised non inferiority test will be adopted. The patients with Candida esophagitis were divided into the yeast group (45 cases) and the nystatin group (44 cases) according to the random digital table method. The two groups were given oral yeast powder and Nystatin Tablets respectively. After the treatment, the gastroscopy was reviewed to evaluate the curative effect. The difference of cure rate between the two groups was compared by non inferiority test. Results: bra The cure rates of yeast and nystatin groups were 68.9% and 63.6%., respectively, using non inferiority test to calculate u=3.027, P=0.0013, and rejection hypothesis. It was considered that the cure rate of yeast was not inferior to that of nystatin. The efficiency of two groups (91.1% and 93.2% respectively) was not statistically significant (P=1.000), but no statistical significance (91.1% and 93.2% respectively). The rate of good reaction was 2.2% and 22.7% respectively, which showed that the yeast group was significantly lower than the nystatin group. The difference was statistically significant (P=0.003). Conclusion: the cure rate of Candida albicans is not inferior to that of nystatin, and the incidence of adverse reaction is low, which can be used as one of the treatment schemes for Candida esophagitis.

【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R571

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