吲哚美辛栓预防高危人群发生内镜逆行胰胆管造影术后胰腺炎给药时机的前瞻性研究

发布时间：2018-05-16 15:49

本文选题：内镜逆行胰胆管造影 + 术后胰腺炎　；参考：《中国内镜杂志》2016年03期

【摘要】：目的探讨吲哚美辛栓预防高危人群发生内镜逆行胰胆管造影(ERCP)术后胰腺炎(PEP)的最佳给药时间。方法 81例患者随机分为A组(术后立即给予吲哚美辛栓100 mg纳肛)、B组(术后30 min给予吲哚美辛栓100 mg纳肛)和C组(单纯常规处理组)。分别测术前、术后3、24及48 h血清C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、血淀粉酶及尿淀粉酶等指标。结果 A组ERCP术后PEP(4.00%)、B组(5.41%)均明显低于C组(26.31%)(P0.05);A组(4.00%)、B组(13.51%)术后高淀粉酶血症发生例数均明显低于C组(31.6%)(P0.05)。A组和B组之间的PEP及高淀粉酶血症发生率差异均无统计学意义(P0.05)。结论 ERCP术后立即或术后30 min经直肠给予吲哚美辛栓100 mg均能够有效降低PEP和术后高淀粉酶血症的发生率。
[Abstract]:Objective to investigate the best time of administration of indomethacin suppository for prevention of pancreatitis after ERCP in high risk population. Methods Eighty-one patients were randomly divided into two groups: group A (100 mg indomethacin suppository) and group C (100 mg indomethacin suppository 100 mg anus after operation) and group C (simple routine treatment group). Serum C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor 伪 (TNF- 伪), serum amylase and urine amylase were measured before, 3h and 48h after operation. Results the incidence of PEP and hyperamylase in group A was significantly lower than that in group C (P 0.05 and P 0.05). The incidence of hyperamylase in group A was significantly lower than that in group C (P 0.05. 05). The incidence of hyperamylase in group A was significantly lower than that in group C (P 0.05.A and B). There was no significant difference in the incidence of PEP and hyperamylase between group B and group A (P 0.05). Conclusion Indomethacin suppository 100mg can effectively reduce the incidence of PEP and hyperamylase after ERCP immediately or 30 min after operation.
【作者单位】：皖南医学院附属芜湖市第二人民医院消化内科;武汉大学人民医院消化内科;
【分类号】：R57

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