泮托拉唑与雷尼替丁治疗十二指肠溃疡的系统评价及药物经济学分析

发布时间：2018-05-17 09:58

本文选题：泮托拉唑 + 雷尼替丁　；参考：《中国药学杂志》2015年13期

【摘要】：目的系统评价泮托拉唑与雷尼替丁比较治疗十二指肠溃疡的有效性和安全性,并分析其药物经济性。方法计算机检索Pub Med、Medline、EMbase、The Cochrane Library、CNKI、VIP和Wan Fang Data,查找有关口服用泮托拉唑与雷尼替丁比较治疗十二指肠溃疡的随机对照试验(RCT),检索时间均为从建库至2014年9月。由2位评价员根据纳入与排除标准独立进行文献筛选、资料提取和质量评价后,采用Rev Man 5.2软件进行Meta分析,并以决策树模型进行成本-效果分析。结果共纳入6个RCT,包括患者1 225例。Meta分析结果显示:2周和4周溃疡治愈率,泮托拉唑均优于雷尼替丁[2周,RR=1.61,95%CI(1.44,1.80),P0.000 01;4周,RR=1.18,95%CI(1.12,1.23),P0.000 01];2周疼痛症状缓解率,泮托拉唑优于雷尼替丁[RR=1.31,95%CI(1.15,1.39),P0.000 01];2周胃肠道症状缓解率,泮托拉唑优于雷尼替丁[RR=1.18,95%CI(1.08,1.28),P=0.000 3];不良反应发生率,泮托拉唑与雷尼替丁相当[RR=1.35,95%CI(0.87,2.10),P=0.19];成本-效果比,雷尼替丁优于泮托拉唑(29.33 vs 53.90)。结论现有证据表明,泮托拉唑为治疗十二指肠溃疡较为有效的方案,雷尼替丁为较为经济的方案,而两者安全性相当且耐受性较好,可根据患者实际情况进行个体化选择。
[Abstract]:Objective to evaluate the efficacy and safety of pam Tora and ranitidine in the treatment of duodenal ulcer. Methods Pub Medline was searched by computer for the Cochrane Library Pub and Wan Fang Data, for the randomized controlled trial of oral pantazol and ranitidine in the treatment of duodenal ulcer. The retrieval time was from the establishment of the library to September 2014. According to the criteria of inclusion and exclusion, two evaluators independently carried out literature screening, data extraction and quality evaluation, then Rev Man 5.2 software was used to carry out Meta analysis, and decision tree model was used to carry out cost-effect analysis. Results A total of 6 RCTs were included, including 1 225 patients. Meta-analysis showed that the cure rate of ulcers at 2 and 4 weeks was better than ranitidine. Pam Tora was better than ranitidine. Pam Tora was superior to ranitidine in relieving gastrointestinal symptoms in 2 weeks, and pam Tora was superior to ranitidine in 2 weeks. The incidence of adverse reactions was comparable with ranitidine [RRR1. 3595 CI 0.872.100.19]; Cost-effectiveness ratio, ranitidine was better than Tora 29. 33 vs 53. 904. Conclusion Pam Tora is an effective regimen for duodenal ulcer, ranitidine is a more economical regimen, and both of them are safe and well tolerated, so they can be selected individually according to the actual situation of the patients.
【作者单位】：贵州省人民医院药剂科;
【基金】：十二五国家科技支撑计划课题资助项目(2013BAI06B04)
【分类号】：R573.1

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