九味愈肝免煎颗粒冲剂联合聚乙二醇干扰素治疗HBeAg阳性慢性乙型肝炎患者的临床研究

发布时间：2018-05-18 10:52

本文选题：慢性乙型肝炎 + 聚乙二醇干扰素　；参考：《山东中医药大学》2014年硕士论文

【摘要】：目的：观察并探讨九味愈肝免煎颗粒冲剂联合聚乙二醇干扰素治疗HBeAg阳性慢性乙型肝炎（CHB）的临床疗效。方法：80例HBeAg阳性慢性乙型肝炎患者随机分为2组，均坚持基础治疗：口服利血生20mg3次/日，鲨肝醇片50mg3次/日。治疗组40例，每周皮下注射聚乙二醇干扰素α-2a180ug，九味愈肝免煎颗粒冲剂,每日一剂，每日一次，每周服6天，间隔一天，疗程为48周。对照组40例，每周皮下注射聚乙二醇干扰素α-2a180ug。分别观察治疗第4周、第12周、24周、48周时的肝肾功能、HBeAg/HbeAb血清转换率和HBV DNA水平。结果：48周结束时治疗组和对照组ALT复常率分别为90%和62.5%（P0.05）,HBeAg/HbeAb血清转换率分别为52.5%和27.5%（P0.05）,HBV-DNA的阴转率分别为67.5%和32.5%，，差异有统计学意义（P0.05）。结论：九味愈肝免煎颗粒冲剂联合聚乙二醇干扰素α-2a治疗慢性乙肝具有较好的抑制乙型肝炎病毒复制，改善肝功能及抗纤维化的作用，是临床治疗慢性乙肝值得推荐的方法。
[Abstract]:Objective : To observe and discuss the clinical curative effect of Jiuwei Yugan decoction combined with polyethylene glycol interferon in the treatment of HBeAg positive chronic hepatitis B .

Methods : 80 HBeAg - positive patients with HBeAg - positive chronic hepatitis B were randomly divided into 2 groups , which were treated with 20 mg / day , 50 mg / day , and 50 mg / day , respectively . 40 cases were treated with polyethylene glycol interferon 伪 - 2a180ug / day .

Results : The rates of ALT and HBeAg / HbeAb in the treatment group and control group were 90 % and 62.5 % ( P0.05 ) , respectively . The serum conversion rate of HBeAg / HbeAb was 52.5 % and 27.5 % ( P0.05 ) . The negative conversion rate of HBV - DNA was 67.5 % and 32.5 % , respectively ( P0.05 ) .

Conclusion : Jiuwei Yugan decoction combined with polyethylene glycol interferon 伪 - 2a can inhibit the replication of hepatitis B virus and improve the function of liver function and anti - fibrosis . It is a recommended method for clinical treatment of chronic hepatitis B .
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R512.62

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