铜仁地区丙型肝炎病毒感染的流行病学调查与基因分型研究

发布时间：2018-05-20 00:26

本文选题：丙型肝炎 + 流行病　；参考：《中华医院感染学杂志》2015年18期

【摘要】：目的探讨铜仁地区丙型肝炎病毒感染的流行病学特点以及基因型特点,以给予针对性的干预和预防。方法选取2011年1月-2014年7月体检者20 185名,抽取空腹静脉血测定其血清中丙型肝炎病毒抗体(抗-HCV),统计抗-HCV阳性者临床资料,测定丙型肝炎病毒基因分型及HCV-RNA水平,所有体检者行B超检查,判断其临床预后。结果 20 185名体检者检出HCV感染者246名,阳性率为1.22%;其中男性阳性率为1.40%,高于女性的1.01%(P0.05);年龄20岁阳性率仅为0.45%,明显低于其他各年龄组,年龄60岁者阳性率为1.80%,明显高于其他各年龄组(P0.05);城镇居民阳性率为1.33%,高于农村居民的1.00%(P0.05),不同职业和学历人群抗-HCV阳性率差异无统计学意义;抗-HCV阳性者中119例患者有输血或其他血液制品史,占48.37%,56例有手术史,占22.76%;7例曾经有偿献血,占2.85%,64例患者感染史不详,占26.02%;基因分型以1b型最为常见,检出180名,占73.17%,最为常见;HCV-RNA定量各基因型差异无统计学意义;经B超检查,基因6型和1b/2a型人群均仅有肝损害,基因2a型肝损害者占80.77%,明显高于其他两种基因型者,不同基因型预后差异有统计学意义(P0.05)。结论不同的基因型丙型肝炎预后不同,可通过基因型分析对患者预后进行评估。
[Abstract]:Objective to investigate the epidemiological and genotypic characteristics of hepatitis C virus infection in Tongren. Methods from January 2011 to July 2014, 20 185 healthy persons were selected and their serum anti-HCV antibody (anti-HCV) was determined by fasting venous blood samples. The clinical data of patients with anti-HCV positive were analyzed, and the genotyping and HCV-RNA levels of HCV were determined. All the patients were examined by B-ultrasound to judge their clinical prognosis. Results the positive rate of HCV infection was 1.22 in 20 185 people, the positive rate of male was 1.40, which was higher than that of female, the positive rate of 20 years old was only 0.45, which was significantly lower than that of other age groups. The positive rate of 60 years old was 1.80, which was significantly higher than that of other age groups, the positive rate of urban residents was 1.33, which was higher than that of rural residents. There was no significant difference in anti-HCV positive rate among different occupation and education groups. Of the 119 patients with positive anti-HCV infection, 119 had history of blood transfusion or other blood products, accounting for 48.370.56 cases had history of operation, 22.76 cases had paid blood donation, and 64 cases had an unknown infection history (26.02%), the genotyping was most common in 1b type, 180 cases were detected. The most common genotypes of HCV-RNA were 73.17, and there was no significant difference among the genotypes of HCV-RNA. By B-mode ultrasound, there was only liver damage in the population of gene 6 and 1b/2a, and 80.77 in the patients with type 2a liver damage, which was significantly higher than that in the other two genotypes. The prognosis of different genotypes was significantly different (P 0.05). Conclusion different genotypes of hepatitis C have different prognosis, which can be evaluated by genotypic analysis.
【作者单位】：铜仁市人民医院检验科;贵州省人民医院检验科;
【基金】：贵州省科技厅基金资助项目(黔科合外G字[2012]7046)
【分类号】：R512.63

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