不同疾病胃粘膜中粘蛋白1和粘蛋白2的表达

发布时间：2018-05-24 02:12

本文选题：MUC1 + MUC2　；参考：《青岛大学》2014年硕士论文

【摘要】：目的：本研究旨在通过观察不同疾病胃粘膜中粘蛋白1(Mucinl, MUC1)、粘蛋白2(Mucin2, MUC2)的表达情况,初步探讨MUC1、MUC2表达与胃粘膜癌变过程及MUC1、MUC2表达与幽门螺杆菌(Helicobacter pylori, HP)感染的相关性。方法：随机选取2011年11月至2012年4月就诊于青岛市市立医院,病理诊断为非萎缩性胃炎的患者30例、肠上皮化生患者30例,胃癌患者48例,用免疫组织化学方法检测所有患者胃粘膜中MUC1和MUC2的表达,并同时探讨它们与HP的相关性。结果：(1)非萎缩性胃炎组、肠上皮化生组、胃癌组胃粘膜组织中MUC1的阳性表达率分别为93.33%、86.67%、79.17%,呈逐渐降低的趋势,但三组间MUC1的阳性表达率两两比较差异均无统计学意义(P＞O.05)。MUC2在非萎缩性胃炎组胃粘膜组织中不表达,在肠上皮化生组及胃癌组胃粘膜组织中阳性表达率分别为83.33%、31.25%,且两组间差异有统计学意义(P＞0.05)。(2)HP阳性胃粘膜较HP阴性胃粘膜中MUC1和MUC2的阳性表达率均低,但差异无统计学意义P分别为0.070、0.953,P＞O.05)。结论：本组研究发现从非萎缩性胃炎、肠上皮化生到胃癌组织,MUC1表达呈逐渐下调的趋势,而MUC2仅在肠上皮化生及胃癌组织中表达,提示这种现象可能与胃癌的发生有关。HP感染可能与胃粘膜MUC1、MUC2的阳性表达率下降有关,但其相关性需要进一步研究探讨。
[Abstract]:Objective : To investigate the relationship between MUC1 , MUC2 expression and gastric mucosal carcinogenesis , MUC1 , MUC2 expression and Helicobacter pylori ( HP ) infection by observing the expression of mucin 1 ( Mucinl , MUC1 ) and Mucin 2 ( MUC2 ) in gastric mucosa of different diseases . Methods : From November 2011 to April 2012 , 30 patients with non - atrophic gastritis , 30 patients with non - atrophic gastritis , 48 patients with gastric cancer were randomly selected , and the expression of MUC1 and MUC2 in gastric mucosa of all patients was detected by immunohistochemistry .

Results : ( 1 ) The positive rates of MUC1 were 93.33 % , 86.67 % and 79.17 % in non - atrophic gastritis group , intestinal epithelium group and gastric cancer group respectively . There was no significant difference between the two groups ( P > 0.05 ) .

Conclusion : The expression of MUC1 is gradually down - regulated from non - atrophic gastritis and intestinal epithelium to gastric cancer . MUC2 is only expressed in intestinal epithelium and gastric cancer tissues , suggesting that this phenomenon may be related to the occurrence of gastric cancer . HP infection may be related to the decrease of MUC1 and MUC2 in gastric mucosa , but its correlation needs further study .
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R573

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