甘草泻心汤联合美沙拉嗪对溃疡性结肠炎的疗效及对血清炎症指标的影响

发布时间：2018-06-02 10:29

本文选题：溃疡性结肠炎 + 甘草泻心汤　；参考：《中药材》2017年02期

【摘要】：目的:探讨甘草泻心汤与美沙拉嗪联合治疗溃疡性结肠炎(UC)的临床疗效及对患者血清炎症细胞因子的影响。方法:将88例UC(寒热错杂型)患者随机分为观察组与对照组,每组44例。对照组给予美沙拉嗪缓释颗粒口服,1.0 g/次,4次/天;观察组在对照组基础上加用甘草泻心汤。两组疗程均为2个月,比较两组临床疗效及血清炎症指标变化。结果:观察组临床疗效总有效率、中医证候疗效总有效率均显著高于对照组(P0.05);治疗后观察组中医证候积分、Baron评分及血清TNF-α、IL-8、IL-17、IL-23显著低于对照组(P0.05),IBDQ评分及血清IL-10显著高于对照组(P0.05);观察组复发率显著低于对照组(P0.05)。结论:甘草泻心汤联合美沙拉嗪治疗UC能显著改善患者临床症状及体征、提高患者生活质量。调节血清炎症细胞因子水平、参与免疫调节可能是其治疗UC和预防复发的主要机制。
[Abstract]:Objective: to investigate the clinical effect of combination of Licorice Xiexin decoction and mesalazine in the treatment of ulcerative colitis and the effect on the inflammatory cytokines in patients with ulcerative colitis. Methods: 88 patients with UC (cold and heat disorder) were randomly divided into observation group (n = 44) and control group (n = 44). The control group was treated with mesalazine sustained-release granule for 4 times a day, and the observation group was treated with Licorice Xiexin decoction on the basis of the control group. The two groups were treated for 2 months. The changes of clinical efficacy and serum inflammatory indexes were compared between the two groups. Results: the total effective rate of clinical efficacy in the observation group, The total effective rate of TCM syndromes was significantly higher than that of the control group (P0.05A), the score of TCM syndrome score and the serum TNF- 伪 IL-8IL-17 IL-23 were significantly lower in the observation group than those in the control group (P 0.05) and the serum IL-10 was significantly higher than that in the control group (P 0.05), and the recurrence rate in the observation group was significantly lower than that in the control group (P 0.05). Conclusion: Glycyrrhiza Xiexin decoction combined with mesalazine can significantly improve the clinical symptoms and signs and improve the quality of life of patients with UC. Regulating the level of serum inflammatory cytokines and participating in immunomodulation may be the main mechanism for the treatment of UC and the prevention of recurrence.
【作者单位】：南京中医药大学;东南大学附属中大医院;南京中医药大学盐城附属医院;江苏省中医院;
【基金】：江苏省中医药局科技项目(YB2015181)
【分类号】：R574.62

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