甘草泻心汤联合美沙拉嗪对溃疡性结肠炎的疗效及对血清炎症指标的影响

发布时间：2018-06-02 10:29

本文选题：溃疡性结肠炎 + 甘草泻心汤　；参考：《中药材》2017年02期

【摘要】：目的:探讨甘草泻心汤与美沙拉嗪联合治疗溃疡性结肠炎(UC)的临床疗效及对患者血清炎症细胞因子的影响。方法:将88例UC(寒热错杂型)患者随机分为观察组与对照组,每组44例。对照组给予美沙拉嗪缓释颗粒口服,1.0 g/次,4次/天;观察组在对照组基础上加用甘草泻心汤。两组疗程均为2个月,比较两组临床疗效及血清炎症指标变化。结果:观察组临床疗效总有效率、中医证候疗效总有效率均显著高于对照组(P0.05);治疗后观察组中医证候积分、Baron评分及血清TNF-α、IL-8、IL-17、IL-23显著低于对照组(P0.05),IBDQ评分及血清IL-10显著高于对照组(P0.05);观察组复发率显著低于对照组(P0.05)。结论:甘草泻心汤联合美沙拉嗪治疗UC能显著改善患者临床症状及体征、提高患者生活质量。调节血清炎症细胞因子水平、参与免疫调节可能是其治疗UC和预防复发的主要机制。
[Abstract]:Objective: To explore the effect of combination of glycyrrhizin Decoction and mesalazine in the treatment of ulcerative colitis (UC) and the effect on serum inflammatory cytokines in patients. Methods: 88 cases of UC (cold and hot mixed type) were randomly divided into observation group and control group, 44 cases in each group. The control group was given oral mesalazine sustained-release granules, 1 g/ times, 4 times / day; The two groups were treated with Glycyrrhiza Xiexin Decoction on the basis of the control group. The treatment of the two groups was 2 months, compared the clinical curative effect of the two groups and the changes of serum inflammation index. Results: the total effective rate of the clinical efficacy of the observation group was significantly higher than that of the control group (P0.05). After the treatment, the TCM syndrome score, Baron score and serum TNF- a, IL-8, IL-17, were observed in the observation group. IL-23 was significantly lower than that of the control group (P0.05), the IBDQ score and serum IL-10 were significantly higher than that of the control group (P0.05), and the recurrence rate of the observation group was significantly lower than that of the control group (P0.05). Conclusion: glycyrrhizin decoction combined with mesalazine in the treatment of UC can significantly improve the clinical symptoms and signs, improve the quality of life of the patients, regulate the level of serum inflammatory cytokines and participate in the immunization. Regulation may be the main mechanism for its treatment of UC and prevention of recurrence.
【作者单位】：南京中医药大学;东南大学附属中大医院;南京中医药大学盐城附属医院;江苏省中医院;
【基金】：江苏省中医药局科技项目(YB2015181)
【分类号】：R574.62

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