早期肠内营养支持对重症急性胰腺炎患者炎症反应和免疫功能的影响

发布时间：2018-06-03 13:19

本文选题：重症急性胰腺炎 + 早期肠内营养　；参考：《中国老年学杂志》2015年08期

【摘要】：目的研究早期肠内营养支持对重症急性胰腺炎(SAP)患者炎症反应和免疫功能的影响。方法将60例SAP患者分为实验组和对照组各30例。实验组入院后24~48 h给予肠内营养支持治疗,对照组给予肠外营养,待患者排气排便后5~7 d开始实施肠内营养支持治疗。于入院后第1、5、7、10天检测两组患者血清C-反应蛋白(CRP)、肿瘤坏死因子(TNF)α、白细胞介素(IL)6水平以及外周血T淋巴细胞亚群(CD3+、CD4+和CD4+/CD8+)水平。结果与对照组比较,实验组住院时间明显缩短,住院费用明显减少,感染率和多脏器功能障碍综合征(MODS)发生率明显降低(P0.05)。第1天时两组炎症因子和T淋巴细胞亚群水平比较无差异(P0.05);第5、7、10天实验组CRP、TNF-α、IL-6水平低于对照组,T淋巴细胞亚群水平高于对照组(均P0.05)。结论给予早期肠内营养支持能更好地降低SAP患者急性反应期炎症反应,改善免疫功能。
[Abstract]:Objective to study the effect of early enteral nutrition support on inflammatory response and immune function in patients with severe acute pancreatitis (SAP). Methods 60 patients with SAP were divided into experimental group (n = 30) and control group (n = 30). The experimental group was treated with enteral nutrition at 24 hours after admission, and the control group with parenteral nutrition. The levels of serum C-reactive protein (CRP), tumor necrosis factor TNFa (TNFa), interleukin-6 (IL-6) and peripheral blood T lymphocyte subsets (CD3 / CD 4 and CD4 / CD8) were measured at 10 days after admission. Results compared with the control group, the hospitalization time of the experimental group was significantly shortened, the hospitalization cost was significantly reduced, and the infection rate and the incidence of multiple organ dysfunction syndrome (MODS) were significantly decreased (P 0.05). On the first day, the levels of inflammatory factors and T lymphocyte subsets in the two groups were not different (P 0.05), but the level of CRPnTNF- 伪 IL-6 in the experimental group was lower than that in the control group on the 10th day (all P 0.05). Conclusion early enteral nutrition support can reduce inflammatory response and improve immune function in patients with SAP.
【作者单位】：新疆医科大学第五附属医院急诊科;新疆医科大学第五附属医院普外科;
【分类号】：R576

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