参柴胃苏胶囊联合多潘立酮治疗功能性消化不良的临床疗效分析

发布时间：2018-06-04 12:59

本文选题：柴胃苏胶囊 + 多潘立酮　；参考：《中药药理与临床》2015年06期

【摘要】：目的:观察研究参柴胃苏胶囊与多潘立酮联合应用对功能性消化不良的临床治疗效果。方法:选取2014年4月~2015年4月于我科室就诊的诊断为功能性消化不良的患者60例,按随机数字表法分为治疗组和对照组各30例,治疗组给予参柴胃苏胶囊联合多潘立酮治疗,对照组单独应用多潘立酮治疗。治疗1月后记录两组疗效结果及主要症状变化情况。结果:治疗1月后治疗组主要症状餐后饱胀不适、早饱感上腹痛、上腹烧灼感评分分别为(1.32±0.73、1.83±0.56、1.22±0.75),均明显低于对照组(1.95±0.79、2.42±0.68、1.74±0.87)。治疗1月后治疗组治HAMA/HAMD明显优于对照组;治疗组总有效率90.0%,明显高于对照组76.7%。治疗1月后治疗组治血清胃动素(MTL)及血清生长抑素(SS)水平分别为(218.7±41.2、613.6±52.1)pg/ml明显优于对照组(188.1±30.2、702.1±57.0)pg/ml。两组患者均无明显不良反应。结论:参柴胃苏胶囊联合多潘立酮治疗功能性消化不良,能明显改善患者症状。
[Abstract]:Objective: to observe the clinical effect of Shenchaiweisu capsule combined with domperidone in the treatment of functional dyspepsia. Methods: sixty patients with functional dyspepsia from April 2014 to April 2015 were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated with Shenchaiweisu capsule combined with domperidone. The control group was treated with domperidone alone. After one month of treatment, the curative effect and main symptoms of the two groups were recorded. Results: after 1 month treatment, the main symptoms of the treatment group were fullness and discomfort after meal, early satiety and upper abdominal pain, and the burning sensation scores of the upper abdomen were 1.32 卤0.73U 1.83 卤0.56U 1.22 卤0.75g, respectively, which were significantly lower than those of the control group (1.95 卤0.79t 2.42 卤0.681.74 卤0.87g). The total effective rate of the treatment group was 90.0g, which was significantly higher than that of the control group (76.7g). The levels of serum motilin (MTL) and somatostatin (SS) in the treatment group were 218.7 卤41.2613.6 卤52.1)pg/ml and 188.1 卤30.2702.1 卤57.0pg / ml, respectively. There were no significant adverse reactions in both groups. Conclusion: Shenchaisuisu capsule combined with domperidone can significantly improve the symptoms of patients with functional dyspepsia.
【作者单位】：海南省三亚市人民医院;广州中山医科大学第一附属医院;
【基金】：广东省自然科学基金:9151008901000117
【分类号】：R57

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