傣药“雅解沙把”联合胃三联治疗Hp相关性胃炎的临床疗效观察

发布时间：2018-06-04 23:35

本文选题：傣医药 + Hp相关性胃炎　；参考：《云南中医学院》2016年硕士论文

【摘要】：目的:本课题通过观察治疗前后患者症状、Hp感染情况及不良反应发生情况,评价傣药“雅解沙把”对“丽珠维三联”治疗Hp相关性胃炎的增效减毒作用。方法:课题采用临床开放试验研究,纳入符合傣医“接崩短皇”诊断标准的Hp相关性胃炎患者74例,随机分为治疗组和对照组,治疗组36人,对照组38人。对照组服用抗幽门螺杆菌(Hp)常用西药:丽珠维三联(枸橼酸铋钾片+克拉霉素片+替硝唑片),治疗组在丽珠维三联治疗的基础上加服傣药“雅解沙把”胶囊。两组均以10天作为一疗程,经治疗10天后,分别观察并记录:(1)两组患者治疗前后的症状评分;(2)两组患者的舌苔变化;(3)两组患者治疗过程中出现的不良反应;(4)治疗组患者治疗前后的安全性指标。4周后复查Hp感染情况,观察两组患者的Hp根除率。结果:1.治疗10天后治疗组的症状总积分、胃脘痞满及大便硬结难下症状积分明显低于对照组,差异具有统计学意义(P0.05)。2.治疗10天后两组患者的舌苔分布比较差异具有统计学意义(P0.05)。3.治疗后“接崩短皇”的主要症状胃脘部疼痛、消谷善饥、胃中嘈杂、恶心呕吐的组间比较均无统计学意义(P0.05)。4.治疗组Hp根除率为75.0%,与对照组Hp根除率65.8%比较差异无统计学意义(P0.05)。5.用药后治疗组的安全性指标皆未出现明显异常。比较两组治疗期间不良反应的发生率(P0.05),差异有统计学意义。结论:1.Hp相关性胃炎患者中“接崩短皇”者男性明显多于女性。2.与单独使用三联疗法的患者相比联合使用雅解沙把的患者,胃脘撑胀及大便硬结难下的症状有更明显改善,而胃脘部疼痛、消谷善饥、胃中嘈杂、恶心呕吐等其它主要症状两组间比较则无显著差异。3.经过根除Hp治疗后,联用“雅解沙把”干预的患者飘林勒(黄苔)消退效果明显优于单纯使用丽珠维三联组。说明“雅解沙把”能有效清解体内热邪,防止根除Hp治疗过程中的化热症状。4.“雅解沙把”联合“丽珠维三联”治疗“接崩短皇”的Hp根除率为75.0%。5.“雅解沙把”能有效降低三联疗法的不良反应发生率,临床应用安全有效。
[Abstract]:Objective: to evaluate the synergistic and attenuated effect of Ya Jie Sha Ba (YJB) on the treatment of HP associated gastritis by observing the incidence of HP infection and adverse reactions before and after treatment. Methods: a total of 74 patients with HP associated gastritis were included in the clinical open trial study. They were randomly divided into treatment group (n = 36) and control group (n = 38). The control group took common western medicine of anti-Helicobacter pylori (HP): lizhuwei triple (bismuth potassium citrate tablet clarithromycin tablet tinidazole tablet), the treatment group took "Ya Jie Sha Ba" capsule on the basis of Lizhuwei triple therapy. Both groups took 10 days as a course of treatment, after 10 days of treatment, Observe and record the symptom score before and after treatment in two groups (2) the change of tongue coating in two groups (3) adverse reactions in the course of treatment in two groups) the safety index before and after treatment in the treatment group was 4 weeks after reexamination of HP infection. HP eradication rate was observed in both groups. The result is 1: 1. After 10 days of treatment, the symptom score of the treatment group was significantly lower than that of the control group (P < 0.05). After 10 days of treatment, the difference of tongue coating distribution between the two groups was statistically significant (P 0.05. 3). After treatment, there was no significant difference between the two groups in the symptoms of epigastric pain, stomachache, stomach noise, nausea and vomiting. The eradication rate of HP in the treatment group was 75.0. There was no significant difference between the HP eradication rate of the treatment group and that of the control group (65.8%). The safety indexes of the treatment group were not abnormal. The incidence of adverse reactions during treatment was compared between the two groups (P 0.05), and the difference was statistically significant. Conclusion: 1. The number of male patients with HP associated gastritis was significantly higher than that of female patients with Hp-associated gastritis. Compared with patients treated with triple therapy alone, the symptoms of epigastric distension and stool sclerotherapy were significantly improved in patients with combined use of yajieshaba, while the pain in the stomach, the elimination of good hunger, and the noise in the stomach. There was no significant difference between the two groups in other major symptoms, such as nausea and vomiting. After the eradication of HP therapy, the regression effect of the patients treated with Ya-Jie Sha Ba was better than that of the group treated with Lizhuwei alone. It is shown that "Ya Jie Sha Ba" can effectively clear away the internal heat evil and prevent the eradication of the symptoms of heat reduction in the course of HP treatment. 4. "the eradication rate of HP in combination with Lizhouwei triple therapy was 75.0. 5%. Ya Jie Sha Ba can effectively reduce the incidence of adverse reactions in triple therapy, and its clinical application is safe and effective.
【学位授予单位】：云南中医学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R573.3

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