胃息肉临床特点及其与幽门螺旋杆菌感染的研究

发布时间：2018-06-05 00:52

本文选题：胃息肉 + 幽门螺旋杆菌　；参考：《石河子大学》2017年硕士论文

【摘要】：目的:了解胃镜下胃息肉的病理特征及临床特点,探讨胃息肉的临床特点及其与幽门螺杆菌(HP)感染的关系,为治疗和诊断胃息肉提供帮助及临床依据。方法:回顾分析2015年10月份到2016年10月份石河子大学医学院第一附属医院消化内镜中心行胃镜诊断胃息肉患者的临床资料,分析患者年龄、性别,胃息肉的大小、位置及其与幽门螺杆菌感染之间的关系,从而进一步指导内镜下行微创治疗或者外科手术治疗。由有内镜操作资格的内镜医师对患者的食管、胃底、胃体、胃角、胃窦、十二指肠进行各方面仔细检查,在胃镜检查时如发现胃息肉则根据胃内标志和黏膜特点确定发生的部位,每一病变至少取一块组织进行组织病理学检查,采用HE染色方法检查幽门螺旋杆菌有无感染,详细记录胃息肉数量、形态、大小、部位等。结果:石河子大学医学院第一附属医院2015年10月到2016年10月兵团消化内镜中心检测出门诊及住院胃息肉的患者共779例,其中男性患者248例,女性患者531例,男女比例为1:2.1,年龄在15-90岁,平均年龄55±11岁;本组资料中一共发现息肉976枚,单发息肉632例,多发息肉共147例;高发年龄段41-60岁(58.9%),年龄在15-90岁,58.9%的胃息肉患者年龄在41-60岁之间,单发息肉632例(81.2%),多发息肉147例(18.8%);大多数胃息肉的直径1.0cm,共为694例(89.1%);胃息肉中幽门螺杆菌的感染率为37.7%;不同部位的胃息肉存在大小的差异(P0.05),不同病理类型的胃息肉之间的HP感染也存在差异(P0.05),胃底胃体部息肉HP的感染率高于其他部位(P0.05)。结论:不同部位的胃息肉存在大小的差异,大多胃息肉直径比较小,小于1.0cm,主要位于胃底和胃体;增生性息肉的HP感染率均高于炎性息肉和腺瘤性息肉,增生性息肉的发生可能与HP感染相关;幽门螺旋杆菌感染对于发生在胃底胃体的增生性息肉、炎性息肉较其他部位的上述病理型息肉更密切。
[Abstract]:Objective: to investigate the pathological and clinical features of gastric polyps under gastroscopy, and to explore the relationship between the clinical features of gastric polyps and the infection of Helicobacter pylori (HP) in order to provide help and clinical basis for the treatment and diagnosis of gastric polyps. Methods: the clinical data of patients with gastric polyps diagnosed by endoscopy in the first affiliated Hospital of Shihezi University Medical College from October 2015 to October 2016 were analyzed retrospectively. The age, sex and size of gastric polyps were analyzed. Location and its relationship with Helicobacter pylori infection further guide endoscopic minimally invasive or surgical treatment. The patients' esophagus, fundus, body, horn, antrum and duodenum were carefully examined by a qualified endoscopic physician. If a gastric polyp was found at the time of gastroscopy, the location of gastric polyp was determined according to the characteristics of the stomach and mucosa. At least one piece of tissue was taken for histopathological examination, and HE staining was used to detect the infection of Helicobacter pylori. Record the number, shape, size and location of gastric polyps in detail. Results: from October 2015 to October 2016, 779 patients with gastric polyps were detected in the first affiliated Hospital of Shihezi University Medical College, including 248 male patients and 531 female patients. The ratio of male and female was 1: 2.1, aged 15-90 years, with an average age of 55 卤11 years. A total of 976 polyps, 632 single polyps and 147 multiple polyps were found in this group, and 41-60 years old, 58.9% of the patients with gastric polyps aged 15-90 years were between 41-60 years old. 632 cases of single polyp and 147 cases of multiple polyps were compared to 18.8%; the diameter of most gastric polyps was 1.0 cm, 694 cases were 89. 1%; the infection rate of Helicobacter pylori in gastric polyps was 37. 7%; there were differences in the size of gastric polyps in different parts (P 0. 05), and in different pathological types of gastric polyps. The infection rate of HP in gastric fundus gastric body polyp was higher than that in other parts. Conclusion: there are differences in the size of gastric polyps in different parts, the diameter of most gastric polyps is smaller than 1.0 cm, mainly located in the stomach fundus and gastric body, the HP infection rate of proliferative polyps is higher than that of inflammatory polyps and adenomatous polyps. The occurrence of proliferative polyps may be related to HP infection, and Helicobacter pylori infection is more closely related to the pathological polyps of the gastric fundus than that of the inflammatory polyps in the gastric fundus.
【学位授予单位】：石河子大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R573

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