D-二聚体在肝硬化患者中的临床应用价值

发布时间：2018-06-11 12:13

本文选题：肝硬化 + D-二聚体　；参考：《吉林大学》2017年硕士论文

【摘要】：目的:探讨肝硬化患者在不同Child-Pugh分组之间D-二聚体水平有无差异及其临床意义。方法:统计2015年1月至2016年12月两年间于我院住院的并行D-二聚体检查的肝硬化患者,共235例,统计其相关的化验指标,并进行回顾性分析,按照Child-Pugh评分分为Child A级(A组),Child B级(B组),Child C级(C组),应用T检验两两比较血浆中D-二聚体(D-D)、胆碱酯酶(CHE)、白蛋白(ALB)、血钙(Ca2+)、胆固醇(CHO)、血小板(PLT)、凝血酶原时间(PT)、总胆红素(TBIL)、碱性磷酸酶(ALP)、甲胎蛋白(AFP)水平。结果:1、随着Child-Pugh积分升高,肝硬化患者血清中D-二聚体、总胆红素、凝血酶原时间升高,B组与A组,C组与B组应用T检验进行两两比较,组间差异均具有统计学意义(P0.05),2、随着Child-Pugh积分升高,血清中胆碱酯酶、白蛋白、血钙、胆固醇水平逐渐下降,应用T检验比较B组与A组、C组与B组之间的差异,均具有统计学意义(P0.05)。而碱性磷酸酶、甲胎蛋白、血小板水平在三组间的差异没有统计学意义(P0.05)。结论:对于肝硬化患者来说,肝脏功能受损越严重,D-二聚体升高的幅度越大。D-二聚体可指导判断肝病预后,在临床上结合其他相关生化指标,可以更准确的评估肝脏损害程度,对相应临床诊治提供重要参考意义。
[Abstract]:Objective: to investigate the difference of D-dimer level among different Child-Pugh groups in patients with liver cirrhosis and its clinical significance. Methods: 235 patients with liver cirrhosis who were hospitalized in our hospital from January 2015 to December 2016 were analyzed retrospectively. According to Child-Pugh score, the patients were divided into two groups: group A, group B, group C, the plasma D-dimer, cholinesterase, Albumin, calcium, cholesterol, platelets, PLTT, prothrombin time, total bile duct were compared by T test. TBILA, ALP, AFP levels. Results with the increase of Child-Pugh score, the serum levels of D-dimer, total bilirubin and prothrombin time increased in patients with liver cirrhosis. With the increase of Child-Pugh score, the serum levels of cholinesterase, albumin, serum calcium and cholesterol gradually decreased. The T test was used to compare the difference between group B and group A and group C and group B. All of them had statistical significance (P 0.05). There was no significant difference in alkaline phosphatase, alpha-fetoprotein and platelet levels among the three groups (P 0.05). Conclusion: for patients with liver cirrhosis, the more serious the liver function damage is, the greater the extent of elevation of D-dimer. D- dimer can guide the prognosis of liver disease, and can be used to evaluate the degree of liver damage more accurately in clinic, combined with other related biochemical indexes. To provide an important reference for the corresponding clinical diagnosis and treatment.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R575.2

【相似文献】