莫西沙星三联疗法治疗幽门螺杆菌感染有效性及安全性的系统评价

发布时间：2018-06-11 20:13

本文选题：幽门螺杆菌感染 + 莫西沙星　；参考：《山东医药》2015年39期

【摘要】：目的系统评价莫西沙星三联疗法治疗幽门螺杆菌(Hp)感染的有效性和安全性。方法计算机检索中国生物医学文献数据库、中国知网、万方医药期刊数据库、维普数据库、Cochrane Central Register of Controlled Trials、Pub Med、Embase数据库,收集国内关于莫西沙星三联疗法治疗Hp感染的随机对照试验,检索时限均为建库至2015年5月。根据纳入与排除标准筛选文献、提取资料、评价偏倚风险后,采用Rev Man5.3软件进行Meta分析。结果最终纳入7篇文献,共593例患者,其中观察组(采用以莫西沙星为基础的三联疗法)297例、对照组(采用以克拉霉素为基础的标准三联疗法)296例。观察组Hp根除率为88.9%,对照组Hp根除率为71.39%,两组差异有统计学意义(RR=1.25,95%CI为1.15~1.35,P0.000 01)。观察组总不良反应发生率低于对照组(RR=0.56,95%CI为0.36~0.89,P=0.01)。本Meta分析结果较稳定。纳入文献无明显发表偏倚。结论莫西沙星三联疗法治疗Hp感染Hp根除率较高,总不良反应发生率较标准三联疗法低。
[Abstract]:Objective to evaluate the efficacy and safety of moxifloxacin triple therapy in the treatment of Helicobacter pylori (HP) infection. Methods to search the database of Chinese biomedical literature, China Zhiwang, Wanfang medical journal database, Weip database and Cochrane Central Register of controlled Trialsof Pub Med-Embase database, and collect the randomized controlled trials of moxifloxacin triple therapy for HP infection in China. The time limit for retrieval is to build the database until May 2015. According to the inclusion and exclusion criteria, the data were extracted, the bias risk was evaluated, and Meta-analysis was carried out with Rev Man5.3 software. Results A total of 593 patients were included in 7 articles, including 297 cases in the observation group (treated with moxifloxacin based triple therapy) and 296 cases in the control group (treated with clarithromycin based standard triple therapy). The eradication rate of HP in the observation group was 88.9 and that in the control group was 71.39. The difference between the two groups was statistically significant. The incidence of total adverse reactions in the observation group was lower than that in the control group. The results of Meta-analysis were stable. There was no obvious publication bias in the included literature. Conclusion Moxifloxacin triple therapy has a higher eradication rate of HP infection and a lower incidence of total adverse reactions than standard triple therapy.
【作者单位】：遵义医学院附属医院;遵义医学院循证医学中心;循证医学教育部网上合作研究中心遵义医学院分中心;
【基金】：贵州省科技厅社会发展攻关基金资助项目(SY20113056)
【分类号】：R573.1

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