血清IL-23、vaspin和fstl1水平在溃疡性结肠炎病情评估中的价值

发布时间：2018-06-12 15:07

本文选题：溃疡性结肠炎 + 白细胞介素　；参考：《山东医药》2015年13期

【摘要】：目的探讨血清IL-23、内脏脂肪特异性丝氨酸蛋白酶抑制剂(vaspin)和卵泡抑素样蛋白1(fstl1)水平在溃疡性结肠炎(UC)病情评估中的价值。方法选择UC患者96例(UC组),其中缓解期35例、活动期61例(轻度15例、中度35例、重度11例),另选健康体检者100例作为对照组,比较两组血清IL-23、vaspin和fstl1水平。结果与对照组比较,UC组血清IL-23、vaspin和fstl1水平明显增高(P均0.05),且活动期UC患者各指标水平较缓解期更高(P均0.05)。活动期UC患者随着病情加重,血清IL-23、vaspin和fstl1水平逐渐升高(P均0.05)。结论血清IL-23、vaspin和fstl1水平对UC严重程度的早期判断具有一定临床参考价值。
[Abstract]:Objective to investigate the value of serum IL-23, visceral fat specific serine protease inhibitor (vaspin) and follicle-like protein (fstl1) in the evaluation of ulcerative colitis (UC). Methods 96 patients with UC were selected as control group, including 35 cases in remission period, 61 cases in active stage (mild 15 cases, moderate 35 cases, severe 11 cases) and 100 healthy persons as control group. The serum levels of IL-23 vaspin and fstl1 were compared between the two groups. Results compared with the control group, the serum levels of IL-23 vaspin and fstl1 in the UC group were significantly higher than those in the control group (P 0.05), and the levels of each index in the active UC patients were higher than those in the remission stage (P 0.05). The serum levels of IL-23 vaspin and fstl1 increased gradually with the exacerbation of active UC patients (P < 0.05). Conclusion Serum levels of IL-23 vaspin and fstl1 may be useful for early diagnosis of UC severity.
【作者单位】：中国医科大学附属第四医院;
【分类号】：R574.62

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