肝脏局灶性病变第3代双源CT双能成像参数与灌注成像参数的相关性

发布时间：2018-06-14 23:09

本文选题：第代双源CT + 碘图　；参考：《中国医学科学院学报》2017年01期

【摘要】：目的研究对于肝脏局灶性病变,第3代双源CT的双能成像碘图参数与灌注成像灌注参数的相关性。方法以2015年11月至2016年8月在北京协和医院经临床诊断为肝脏非囊性占位的33例患者为研究对象,运用第3代双源CT行肝脏灌注成像及双能CT成像扫描,两种扫描间隔15 min。于双能CT动、门脉期碘图肝占位相对高、中、低密度区及正常肝右叶、肝左叶实质内绘制感兴趣区(ROI),获得碘图CT值;于肝脏灌注图像的相同位置绘制ROI,获得肝动脉灌注量(ALP)、门静脉灌注量(PVP)、肝动脉灌注指数(HPI)。采用Pearson相关性分析比较碘图CT值与灌注参数相关性。结果动脉期碘图CT值与ALP(r=0.812,95%CI=0.728~0.885,P0.001)和PVP(r=-0.209,95%CI=-0.323~-0.073,P=0.007)显著相关,与HPI无显著相关(r=0.058,95%CI=0.046~0.498,P=0.461)。门脉期碘图CT值与PVP显著相关(r=0.214,95%CI=0.072~0.361,P=0.005),与HPI无显著相关(r=0.036,95%CI=-0.002~0.242,P=0.649)。双能CT扫描动脉期和门脉期的总有效剂量为(3.53±1.17)m Sv,明显低于肝脏灌注的(14.53±0.45)m Sv(t=25.212,P0.001)。结论双能CT成像动脉期碘图参数与肝脏灌注ALP和PVP显著相关,门脉期碘图参数与PVP显著相关。
[Abstract]:Objective to study the correlation between dual-energy imaging iodine parameters and perfusion imaging parameters of the third generation dual-source CT for focal liver lesions. Methods from November 2015 to August 2016, 33 patients who were clinically diagnosed as non-cystic occupying liver in Peking Union Hospital were studied. The third generation dual-source CT was used to perform hepatic perfusion imaging and dual-energy CT imaging. The interval between the two scans was 15 minutes. The right lobe of normal liver and the middle and low density area of the liver were drawn in the middle and low density area of the liver and the right lobe of the normal liver. The region of interest was drawn in the Zuo Ye parenchyma of the liver, and the CT value of the iodine graph was obtained. ROI was drawn at the same position of hepatic perfusion image to obtain hepatic artery perfusion volume (ALP), portal vein perfusion volume (PVP), hepatic artery perfusion index (HPI) and hepatic artery perfusion index (HPI). Pearson correlation analysis was used to compare the correlation between CT value and perfusion parameters. Results the CT value of arterial phase iodide was significantly correlated with ALP rn 0.812 ~ 95 CIQ 0.728 0.885U P0.001) and PVPr-0.209 ~ 95C CI-0.323- 0.073P0. 007), but not with HPI (r0.0595CI0.0460.498P0. 461 ~ 0. 461 ~ 0. 461 ~ 0. 461 ~ 0. 461 ~ 0. 595 CI 0.046 ~ 0. 498P ~ 0. 461 ~ 0. 461 ~ 0. 461 ~ 0. 461 ~ 0. 461). The CT value of portal phase iodography was significantly correlated with PVP (r = 0.214995), but had no significant correlation with HPI (n = 0.036,95CI-0.002 ~ 0.242P ~ (0.649). The total effective dose in arterial phase and portal phase was 3.53 卤1.17mSv, which was significantly lower than that in hepatic perfusion group (14.53 卤0.45mSvt, 25.212mSvt, P 0.001). Conclusion the arterial phase iodine parameters of dual-energy CT imaging are significantly correlated with hepatic perfusion of ALP and PVP, and portal phase iodine parameters are significantly correlated with PVP.
【作者单位】：中国医学科学院北京协和医学院北京协和医院放射科;中国医学科学院北京协和医学院北京协和医院肝脏外科;
【基金】：国家临床重点专科建设项目(2014) 卫生公益性行业科研专项项目(201402019)~~
【分类号】：R816.5;R575

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