慢性乙型肝炎患者医院感染病原菌分析与病原学研究

发布时间：2018-06-17 05:56

本文选题：慢性乙型肝炎 + 医院感染　；参考：《中华医院感染学杂志》2015年12期

【摘要】：目的探讨慢性乙型肝炎患者医院病原菌感染的临床特点及病原学分析,为临床预防医院感染提供有利依据。方法选取2010年12月-2013年12月慢性乙型肝炎患者240例,依据不同年龄段进行分组,对比其感染率,通过菌株培养及鉴定判断引起感染的病原菌分布,分析感染的临床特点,明确慢性乙型肝炎患者易感染部位。结果 240例慢性乙型肝炎患者发生医院感染73例、84例次,感染率30.42%、例次感染率35.00%;73例感染患者中52例为多重感染,共分离出病原菌131株,其中革兰阴性菌占33.59%、革兰阳性菌占14.50%、真菌占51.91%;医院感染部位主要以腹腔为主占38.10%,其次为下呼吸道占15.48%;引起52例患者病原菌感染的因素主要为抗菌药物的滥用。结论感染是慢性乙型肝炎患者最多见的并发症之一,也是肝衰竭最终导致多脏器功能衰竭的始动原因,因此临床要加强慢性乙型肝炎患者医院感染相关危险因素的控制,依据病原学分析合理应用抗菌药物,积极预防与治疗感染是提高重型肝炎存活率的重要环节。
[Abstract]:Objective to investigate the clinical characteristics and etiological analysis of nosocomial pathogens infection in patients with chronic hepatitis B (CHB) so as to provide a favorable basis for clinical prevention of nosocomial infection. Methods 240 patients with chronic hepatitis B from December 2010 to December 2013 were divided into groups according to different age groups, the infection rate was compared, the distribution of pathogenic bacteria caused by infection was judged by strain culture and identification, and the clinical characteristics of infection were analyzed. To identify the site of infection in patients with chronic hepatitis B. Results there were 84 nosocomial infections in 240 patients with chronic hepatitis B. the infection rate was 30.422.The infection rate was 35.00%. 52 cases were multiple infections, and 131 strains of pathogenic bacteria were isolated. Gram-negative bacteria accounted for 33.59m, Gram-positive bacteria 14.50m, fungi 51.91%, the nosocomial infection sites mainly consisted of abdominal cavity 38.10%, lower respiratory tract 15.48m, and the main causes of pathogenic bacteria infection in 52 patients were the abuse of antimicrobial agents. Conclusion infection is one of the most common complications in patients with chronic hepatitis B, and it is also the initial cause of multiple organ failure caused by liver failure. Therefore, it is necessary to strengthen the control of risk factors related to nosocomial infection in patients with chronic hepatitis B. It is an important link to improve the survival rate of severe hepatitis by rational application of antimicrobial agents and active prevention and treatment of infection according to etiological analysis.
【作者单位】：南昌大学第一附属医院感染科;
【基金】：江西省卫生厅规划基金资助项目(JW-2011B030)
【分类号】：R512.62

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