骶神经刺激对不同分型功能性便秘的动力学影响及疗效观察

发布时间：2018-06-25 03:19

本文选题：骶神经刺激 + 功能性便秘　；参考：《青岛大学》2014年硕士论文

【摘要】：目的：观察骶神经刺激对功能性便秘的疗效,并从排便动力学评估骶神经电刺激后对排便功能的影响并分析可能存在的机制,为骶神经刺激治疗临床不同分型便秘提供客观依据。方法：1、选取明确诊断的功能性便秘患者180例,分为结肠慢传输型60例,出口梗阻型60例,混合型60例,采用数字随机法随机分为两组。2、对照组予单纯福松口服,治疗组在福松治疗的基础上加用骶神经刺激治疗,治疗以20日为1疗程。3、在治疗前及治疗后分别进行结直肠动力学检查,并以便秘患者症状评分及生活质量问卷评分(PAC-QOL)为主要观察指标,疗程结束后,两组疗效作组间比较。结果：1、治疗组动力学指标较治疗前显著降低,与对照组相比较有显著差异(P0.05),表明治疗组疗效明显优于对照组。2、治疗组与对照组的便秘症状评分治疗前与治疗后相比有显著性差异(P0.05),两组间临床症状评分相比较有显著性差异(P0.05),表明治疗组疗效明显优于对照组。3、治疗组与对照组的PAC-QOL评分治疗前与治疗后相比有显著性差异(P0.05),两组患者生活质量均明显提高,两组间PAC-QOL评分相比较有显著性差异(P0.05),表明治疗组疗效明显优于对照组。结论：SNS是创伤小、疗效好的治疗功能性便秘的方法,可显著改善患者的症状,提高患者的生活的质量,改善结直肠动力,协调盆底肌群运动,降低排便阈值。
[Abstract]:Objective: To observe the effect of sacral nerve stimulation on functional constipation, and to evaluate the effect of sacral nerve stimulation on defecation after the electric stimulation of the sacral nerve and to analyze the possible mechanisms of the sacral nerve stimulation, so as to provide an objective basis for the treatment of different clinical constipation by sacral nerve stimulation.
Methods: 1, 180 cases of functional constipation were selected and divided into 60 cases of colon slow transmission type, 60 cases of outlet obstruction type and 60 cases of mixed type. The patients were randomly divided into two groups of.2 by digital random method. The control group was given simple Fu Song oral administration. The treatment group was treated with sacral nerve stimulation on the basis of the treatment of Fu Song. The treatment was treated with 20 days as the 1 course of treatment, and the treatment was treated in the treatment of.3. The treatment group was treated with the treatment of 20 days. Colorectal kinetics was performed before and after treatment, and the symptoms score of constipation patients and quality of life questionnaire (PAC-QOL) were used as the main indexes. After the course of treatment, the two groups were compared.
Results: 1, the dynamic indexes of the treatment group were significantly lower than those before the treatment (P0.05), which showed that the curative effect of the treatment group was significantly better than that of the control group.2. The constipation symptom scores of the treatment group and the control group were significantly different before and after the treatment (P0.05), and there was a significant difference in the clinical symptom scores between the two groups (P0.05). P0.05) showed that the curative effect of the treatment group was obviously better than that of the control group.3. The PAC-QOL score of the treatment group and the control group was significantly different before and after the treatment (P0.05). The quality of life of the two groups was obviously improved, and the PAC-QOL score of the two groups was significantly different (P0.05), indicating that the curative effect of the treatment group was obviously better than that of the control group.
Conclusion: SNS is a minimally invasive and effective method for the treatment of functional constipation. It can significantly improve the patient's symptoms, improve the quality of the patient's life, improve the dynamic of the colorectal, coordinate the movement of the pelvic floor muscle group, and reduce the threshold of defecation.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R574.62

【引证文献】