急性胰腺炎患者外周血血浆中中性粒细胞明胶酶相关脂质运载蛋白的浓度变化及其意义

发布时间：2018-06-25 06:38

本文选题：胰腺炎 + 中性粒细胞明胶酶相关脂质运载蛋白　；参考：《中国普通外科杂志》2017年09期

【摘要】：目的:检测分析急性胰腺炎(AP)患者外周血中性粒细胞明胶酶相关脂质运载蛋白(NGAL)的动态变化及其临床意义。方法:选取收治的117例AP患者,依据病情分为急性轻症胰腺炎(轻症组)60例,急性重症胰腺炎(重症组)57例;同时选取体检中心收集的健康自愿者60例作为健康组,分别检测三组研究对象的NGAL等指标并进行统计分析。结果:在入院后第1、3、7天重症组患者的外周血抵抗素、hs-CRP、NGAL、血淀粉酶、PCT测定值均显著的高于轻症组和健康组(P0.05);轻症组患者入院后第1、3天的外周血抵抗素、hs-CRP、NGAL、血淀粉酶、PCT测定值显著的高于健康组(P0.05);轻症组患者入院后第7天的血淀粉酶、PCT测定值显著的高于健康组(P0.05)。重症组患者的APACHE II评分在入院后第1、3、7天均显著的高于轻症组患者(P0.05)。重症组患者的Balthazar CT评分在入院后第1、7天均显著的高于轻症组患者(P0.05)。AP患者外周血NGAL水平与其外周血抵抗素、hs-CRP、PCT、PACHE II评分、Balthazar CT评分均呈正相关(P0.05)。结论:NGAL与AP患者病情严重程度具有显著关系,可作为临床治疗重要的参考指标。
[Abstract]:Objective: to detect and analyze the dynamic changes and clinical significance of neutrophil gelatinase related lipid carrier protein (NGAL) in peripheral blood of patients with acute pancreatitis (AP) and its clinical significance. Methods: 117 cases of AP patients were selected and divided into 60 cases of acute mild pancreatitis (light disease group) and 57 cases of severe acute pancreatitis (severe group). 60 healthy volunteers were used as the health group to test the NGAL and other indexes of three groups of subjects. Results: the peripheral blood resistin, hs-CRP, NGAL, blood amylase and PCT were significantly higher than those of the mild group and the healthy group (P0.05) at the first 1,3,7 day after admission, and the patients in the light group were given 1,3 days after admission. The values of peripheral blood resistin, hs-CRP, NGAL, blood amylase and PCT were significantly higher than that in the healthy group (P0.05). The serum amylase in the light syndrome group was significantly higher than that in the healthy group (P0.05) at seventh days after admission. The APACHE II score in the severe group was significantly higher than that in the light group (P0.05) at the 1,3,7 day after admission. The Azar CT score was significantly higher than that of the patients in the light disease group (P0.05) on day 1,7. The level of peripheral blood NGAL in the peripheral blood of the patients with.AP was positively correlated with the peripheral blood resistin, hs-CRP, PCT, PACHE II score and Balthazar CT score.
【作者单位】：山西医科大学汾阳学院临床医学系消化教研室;山西省汾阳医院消化科;
【基金】：山西医科大学汾阳学院科研基金资助项目(2017B04)
【分类号】：R576

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