体素内不相干运动扩散加权成像评价胰腺纤维化的初步研究

发布时间：2018-06-25 11:39

本文选题：胰腺疾病 + 纤维化　；参考：《中国临床医学影像杂志》2017年10期

【摘要】：目的:探讨磁共振体素内不相干运动扩散加权成像(IVIM-DWI)在胰腺纤维化评价中的价值。方法 :收集15例健康志愿者(对照组)及45例胰头体部或壶腹部病变并行胰十二指肠切除术的患者(病变组),病变组术前一周内均行3.0T IVIM-DWI检查及术后胰腺断端纤维化分期评价(F0期15例,F1期10例,F2期11例,F3期9例),由两名具有5年以上腹部影像诊断经验的放射科医师于胰腺断端处绘制感兴趣区(ROI),测得真实扩散系数(D),假性扩散系数(D*)及灌注分数(f)值,采用Spearman秩相关系数及受试者工作特性曲线(ROC)分析D、D*、f值与胰腺纤维化间的相关性及诊断胰腺纤维化分期的效能。结果:两名测量者间测得受试者的D、D*、f值的一致性良好(ICC:0.925、0.907、0.823)。f值与纤维化分期的相关性略高于D和D*(Spearman相关性检验:r=-0.651、-0.392、-0.523,P分别为0.001、0.002、0.001)。f值区分F0/(F1~F3)期、(F0,F1)/(F2,F3)的曲线下面积略高于D及D*(F0比(F1~F3):0.822、0.662、0.764;(F0,F1)比(F2,F3):0.876、0.772、0.799),但差异无统计学意义(P均大于0.05)。结论:IVIM-DWI成像是一种良好的胰腺纤维化的分期方法。
[Abstract]:Objective: To investigate the value of incoherent motion diffusion-weighted imaging (IVIM-DWI) in the evaluation of pancreatic fibrosis. Methods: 15 healthy volunteers (control group) and 45 patients with pancreatic head body or ampullary duodenectomy were collected and treated with 3.0T IVIM-DWI examination in one week before the operation. The fibrosis stages of the pancreatic broken end were evaluated (15 cases in F0, 10 in F1, 11 in F2, 9 in F3). Two radiologists with more than 5 years of abdominal imaging were plotted the region of interest (ROI) at the broken end of the pancreas. The true diffusion coefficient (D), pseudodiffusivity coefficient (D*) and perfusion fraction (f) were measured, and the Spearman rank correlation coefficient was used. The relationship between D, D*, F value and pancreatic fibrosis and the diagnosis of pancreatic fibrosis staging were analyzed by the subjects' work characteristic curve (ROC). Results: the correlation between the D, D*, F values of the subjects was better than the D and D* (Spearman correlation test) between the two subjects. .392, -0.523, P are 0.001,0.002,0.001).F values of F0/ (F1~F3), and (F0, F1) / (F2, F3) are slightly higher than D and 0.001,0.002,0.001; but there is no statistically significant difference (all greater than 0.05).
【作者单位】：中国医科大学附属盛京医院放射科;飞利浦影像研究学院;
【基金】：国家自然科学基金面上项目(81471718,81401376) 中国医科大学国家自然科学基金优秀青年科学基金培育项目(YQ20160005) 盛京杰出人才计划(Sjjcrc-01)
【分类号】：R445.2;R576

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