蛇毒诱导凝固抑制试验判断肝硬化凝血状态

发布时间：2018-06-27 12:41

  本文选题：PICI% + 肝硬化　； 参考：《广东医学》2016年10期

【摘要】：目的研究常规凝血指标在肝硬化患者的变化,探讨蛇毒诱导凝固抑制试验(PICI%)在判断肝硬化凝血状态的临床价值。方法收集肝硬化患者236例,正常对照组90例。均进行凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、PICI%的检测。结果 (1)肝硬化患者的PT明显高于对照组(P0.01),随病情加重逐渐延长,而PICI%明显低于对照组(P0.01),随肝功能分级变差逐渐降低,且两指标在对照组、Child-Pugh A、B、C间两两比较差异均有统计学意义(P0.01)。(2)PICI%与PT呈负相关,且相关关系密切(相关系数r=0.649,P0.01)。结论 PICI%能够有效反映肝硬化患者的高凝状态,可作为临床准确判断肝硬化出血或血栓的指标。PT、PICI%均可作为临床评估肝硬化患者病情进展及预后的指标。
[Abstract]:Objective to study the changes of routine coagulation parameters in patients with liver cirrhosis and to explore the clinical value of snake venom induced coagulation inhibition test (PICI%) in judging the coagulation state of cirrhosis. Methods 236 cirrhotic patients and 90 normal controls were collected. Prothrombin time (PT), activated partial thromboplastin time (APTT) and PICI% were measured. Results (1) PT of patients with liver cirrhosis was significantly higher than that of the control group (P0.01), and the PICI% was significantly lower than that of the control group (P0.01). There was a negative correlation between PICI% and PT in the control group (P 0.01). (2), and there was a close correlation between the two indexes (r = 0. 649%, P 0. 01). Conclusion PICI% can effectively reflect the hypercoagulable state of the patients with liver cirrhosis and can be used as a clinical accurate index to judge the bleeding or thrombus in cirrhosis. PICI% can be used as an index to evaluate the progression and prognosis of the patients with liver cirrhosis.
【作者单位】： 广州医科大学附属广州市第一人民医院消化科、广州消化疾病研究所;广东省广州市第八人民医院消化科;广州医科大学附属第二医院消化科;
【基金】：广东省广州市胃肠病医学研究与转化中心资助项目(编号:201508020001)
【分类号】：R575.2
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本文编号：2073952